Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SEP-363856 hydrochloride (SEP-856 hydrochloride) is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to treatment of schizophrenia.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 249.00 | |
10 mg | In stock | $ 416.00 | |
25 mg | In stock | $ 692.00 | |
50 mg | In stock | $ 985.00 | |
100 mg | In stock | $ 1,330.00 | |
500 mg | In stock | $ 2,660.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 273.00 |
Description | SEP-363856 hydrochloride (SEP-856 hydrochloride) is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to treatment of schizophrenia. |
Targets&IC50 | 5-HT2C receptor:30 μM (EC50), 5-HT1D receptor:0.262 μM (EC50), 5-HT1A receptor:2.3 μM (EC50), 5-HT7 receptor:6.7 μM (EC50), 5-HT1B receptor:15.6 μM (EC50), 5-HT2A receptor:10 μM (EC50), TAAR1:0.140 μM (EC50) |
In vitro | SEP-856 (10μM) specifically inhibits α2A, α2B, D2, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C and 5-HT7> 50% receptor. |
In vivo | SEP-856 (0.3, 1 and 10 mg/kg, i.p.) is CNS active. SEP-856 exhibits a behavioral signature similar to known antipsychotic drugs.PCP-induced hyperactivitysignificantly reduced by SEP-856 (0.3, 1 and 10 mg/kg, orally once) . Oral SEP-856 administration (1, 3 and 10 mg/kg) produces a dosedependent decrease in REM sleep, increase in latency to REM sleep and increase in cumulative wake (W) time. |
Synonyms | SEP-856 hydrochloride |
Molecular Weight | 219.73 |
Formula | C9H14ClNOS |
CAS No. | 1310422-41-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.5 mg/mL (284.44 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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SEP-363856 hydrochloride 1310422-41-3 GPCR/G Protein Neuroscience Others 5-HT Receptor Inhibitor SEP 856 SEP856 SEP-363856 Hydrochloride SEP363856 SEP-856 Hydrochloride SEP-856 hydrochloride SEP 363856 hydrochloride 5-hydroxytryptamine Receptor inhibit Serotonin Receptor SEP363856 Hydrochloride SEP363856 hydrochloride SEP-363856 SEP 363856 SEP-856 SEP856 Hydrochloride SEP 363856 Hydrochloride SEP 856 Hydrochloride inhibitor