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Methiothepin maleate

Catalog No. T4375   CAS 19728-88-2
Synonyms: Metitepine

Methiothepin maleate (Metitepine) is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.

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Methiothepin maleate Chemical Structure
Methiothepin maleate, CAS 19728-88-2
Pack Size Availability Price/USD Quantity
50 mg 6-8 weeks $ 62.00
100 mg 6-8 weeks $ 113.00
500 mg 6-8 weeks $ 423.00
1 mL * 10 mM (in DMSO) 6-8 weeks $ 50.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Methiothepin maleate (Metitepine) is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
Targets&IC50 h5-HT(7) receptor:152 nM
In vivo The intracerebroventricular administration of aftin-4 (3–20 nmol) increased Aβ1-42, but not Aβ1-40, content in the mouse hippocampus, between 5 and 14 days after injection. Aftin-4 injection increased lipid peroxidation levels in the hippocampus, an index of oxidative stress.
Synonyms Metitepine
Molecular Weight 472.62
Formula C24H28N2O4S2
CAS No. 19728-88-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mM

TargetMolReferences and Literature

1. Knight J A, etal. Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists[J]. Molecular Pharmacology, 2009, 75(2):374-380. 2. Rizviä‡ E, etal. Atypical sympathomimetic drug lerimazoline mediates contractile effects in rat aorta predominantly by 5-HT2A receptors[J]. Bosn J Basic Med Sci, 2017, 17(3):194-202.

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Keywords

Methiothepin maleate 19728-88-2 GPCR/G Protein Neuroscience 5-HT Receptor Methiothepin Maleate Metitepine inhibitor inhibit

 

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