hct116 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2099	ABT-737		Mitophagy , BCL , Autophagy
	ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM).		Mitophagy , BCL , Autophagy
T9810	TNIK-IN-5		Wnt/beta-catenin
	TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity.		Wnt/beta-catenin
T9963	MPT0B390		HDAC
	MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis.		HDAC
T8668	HM03		HSP
	HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.		HSP
T8500	VLX600		OXPHOS , Mitochondrial Metabolism , Autophagy
	VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells.		OXPHOS , Mitochondrial Metabolism , Autophagy
T8973	HS-1793		Others
	HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model		Others
T6759	AP-III-a4	ENOblock	Glucokinase
	AP-III-a4 (ENOblock) (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 μM.		Glucokinase
T11898	LXH254		Raf
	LXH254 is a potent C-Raf and B-Raf inhibitor.		Raf
T6255	Bromosporine		Epigenetic Reader Domain , CDK
	Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.		Epigenetic Reader Domain , CDK
T9696	β-catenin-IN-2		Wnt/beta-catenin
	β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.		Wnt/beta-catenin
T8800	NSAH	2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide	DNA/RNA Synthesis
	NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively...		DNA/RNA Synthesis
T1290	Oxiconazole nitrate	Ro 13-8996	Others , Antibiotic , Antifection , Antifungal
	Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole...		Others , Antibiotic , Antifection , Antifungal
T16961	Supinoxin	RX-5902	Apoptosis , DNA/RNA Synthesis
	Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase and a potent first-in-class anti-cancer agent. Supinoxin induces cell apoptosis and inhibits the growth of TNBC cancer cell lines (IC50...		Apoptosis , DNA/RNA Synthesis
T2763	Panaxadiol	20(R)-Panaxadiol	Others , HIF/HIF Prolyl-Hydroxylase
	Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.		Others , HIF/HIF Prolyl-Hydroxylase
T2617	SNS-314 Mesylate	SNS-314	Aurora Kinase
	SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor (IC50: 9/31/3 nM). It is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.		Aurora Kinase
T0132	Etoposide	VP-16,VP-16-213	Apoptosis , Mitophagy , Topoisomerase , Antibacterial , Antibiotic , Autophagy
	Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide has antitumor activity and induces apoptosis and autophagy.
T6583	MG-101	ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101	Cysteine Protease , Proteasome
	MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.		Cysteine Protease , Proteasome
T15396	GN44028	N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine	HIF
	GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. H...		HIF
T6442	CH5138303		HSP
	CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.		HSP
T9078	LY3405105	1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester	CDK
	LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester) is a novel CDK7 inhibitors.		CDK