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MG-101

Catalog No. T6583 CAS 110044-82-1

Synonyms: MG 101, Ac-LLnL-CHO, Calpain inhibitor-1, Calpain inhibitor I, MG101, ALLN

MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MG-101, CAS 110044-82-1

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Purity 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
In vitro	AI-10-49 displays specific growth inhibition of inv(16)-positive cell line ME-1. AI-10-49 selectively binds to CBFβ-SMMHC, disrupts its binding to RUNX1, and restores RUNX1 transcriptional activity. [1]

Synonyms	MG 101, Ac-LLnL-CHO, Calpain inhibitor-1, Calpain inhibitor I, MG101, ALLN
Molecular Weight	383.53
Formula	C20H37N3O4
CAS No.	110044-82-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 76 mg/mL (198.15 mM)

H2O: <1 mg/mL

Ethanol: 76 mg/mL (198.15 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Hiwasa T, et al. Carcinogenesis. 1990, 11(1), 75-80. 2. Inoue S, et al. J Biol Chem. 1991, 266(20), 13311-13317.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Inhibitor Library Covalent Inhibitor Library Anti-COVID-19 Compound Library Ubiquitination Compound Library Apoptosis Compound Library Protease Inhibitor Library Anti-Aging Compound Library 3CLpro-Targeted Compound Library (CADD) Bioactive Compound Library

Related Products

Related compounds with same targets

MG-101 E 64c Leupeptin Hemisulfate NSC 185058 Aureusimine B KGP94 JTE-607 L-006235

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.