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Search Result

Search Results for " h4/a "

42

Compounds

4

Natural Products

158

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T32669 Leucomycin a5 Leukomycin A5,Turimycin H4
Leucomycin a5 is a metabolite from the leucomycin complex, which was originally isolated from S. kitasatoensis. It is active against a variety of Gram-positive and Gram-negative bacteria (MICs = 0.04-0.8 µg/ml) but not a...
T5829 H4 Receptor antagonist 1 Histamine Receptor
H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM.
T3963 VUF10460 Histamine Receptor
VUF10460 is a non-imidazole histamine H4 receptor agonist.
T11723L JNJ-39758979 Histamine Receptor
JNJ-39758979 is a selective and high-affinity histamine H4 receptor antagonist (Kis: 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively). JNJ-39758979 functionally antagonizes histamine...
T34709 ST-1006 ST 1006 Histamine Receptor
ST-1006 is a potent histamine H4 receptor agonist (pKi: 7.94).ST-1006 has anti-inflammatory effects.ST-1006 is a potent inducer of basophil migration and induces basophil migration.ST-1006 is a potent inducer of basophil...
T6980 Scriptaid GCK1026,Scriptide Apoptosis , Influenza Virus , HDAC , Autophagy
Scriptaid (GCK1026) is an inhibitor of HDAC, and has a greater effect on acetylated H4 than H3.
T27083 Crebinostat Epigenetic Reader Domain , Histone Acetyltransferase , HDAC
Crebinostat is a potent histone deacetylase (HDAC) inhibitor, inhibiting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respectively.Crebinostat increases the density of synapsin-1 punct...
T13996 1-Naphthohydroxamic acid HDAC
1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid d...
T8439 Clobenpropit dihydrobromide Apoptosis , Histamine Receptor
Clobenpropit dihydrobromide is a potent antagonist and inverse agonist of histamine H3R (histamine H3LR,pEC50 of 8.07)
T38634 Histamine H4 receptor antagonist-1 Histamine H4 receptor antagonist-1
Histamine H4 receptor antagonist-1 is a potent antagonist of the histamine H4 receptor.
T28746 Seliforant
Seliforant is a histamine H4 receptor antagonist.
T68280 Adriforant
Adriforant, also known as ZPL-3893787, PF-3893787 and ZPL-389, is a novel histamine H4 receptor antagonist. Adriforant shows an excellent in vitro profile that warrants their further investigation in relevant models of ...
T29146 VUF 8430 VUF8430,VUF-8430
VUF 8430 is a selective agonist for the H4 receptor.
T33831 OUP-16 OUP 16,OUP16
OUP-16 is a potent and selective histamine H4 receptor agonist.
T78287 Alsevalimab
Alsevalimab is a human monoclonal antibody targeting B7-H4 [1].
T23597 A-940894 A940894,A 940894
A-940894 is a histamine H4 receptor antagonist with anti-inflammatory properties. A-940894 potently binds to both human and rat histamine H4 receptors and exhibits considerably lower affinity for the human histamine H1, ...
T35004 UR-RG98 UR-RG 98,URRG 98,URRG98,URRG-98,UR-RG-98
UR-RG98 is a potent and selective agonist of human histamine H4 receptor (hH4R).
T72013 Epigenetic Multiple Ligand
Epigenetic Multiple Ligand is a cell-permeable inhibitor of substrate processing by several chromatin-associated enzymes, including SIRT1/2, H3/SET7, H3/p300/CBP, H4/RmtA, PABP1/CARM1, and H4/PRMT1. It acts by inducing e...
T24951 VUF-10497
VUF-10497 is a histamine H4 receptor inverse agonist (pKi = 7.57). VUF-10497 was found to possess anti-inflammatory properties in vivo in the rat. VUF-10497 also possesses a considerable affinity for the human histamine ...
T24998 AC-93253 iodide AC93253 iodide
AC-93253 iodide is a selective inhibitor of SIRT2. It significantly enhances the acetylation of tubulin p53 and histone H4.
T22018 A 987306
A-987306 is a potent and oral bioavailable histamine H 4 antagonist, with Kis of 3.4 nM and 5.8 nM for rat H4, and human H4. A-987306 exhibits anti-inflammatory activity in mice peritonitis model [1].
T81345 Puxitatug
Puxitatug is a human monoclonal antibody of the immunoglobulin G1-κ class, targeting the V-set domain-containing T-cell activation inhibitor 1 (VTCN1, also known as B7 family member H4, B7H4, B7-H4) in Homo sapiens [1].
T24207 JNJ-28610244 JNJ 28610244
JNJ-28610244 is a specific agonist of the H4 receptor. It acts by blocking Mac-1-dependent activation of p38 MAPK.
T27658 JNJ-10191584 VUF-6002,JNJ10191584
JNJ-10191584, a potent and selective antagonist at the histamine H4 receptor, has antiinflammatory and analgesic effects in animal studies of acute inflammation.
TP1536 Histone H4 (2-21)
Histone H4 (2-21) is a pivotal core histone involved in the process of chromatinization specific to the genomes of herpes simplex virus 1 (HSV-1).
T69918 Adriforant tartrate hydrate
Adriforant tartrate hydrate, also known as ZPL-3893787 tartrate hydrate, PF-3893787 tartrate hydrate and ZPL-389 tartrate hydrate, is a novel histamine H4 receptor antagonist. Adriforant tartrate hydrate shows an excelle...
T74735 Gly-Cyclopropane-Exatecan
Gly-Cyclopropane-Exatecan, a DNA Topoisomerase I inhibitor containing Exatecan, is key in synthesizing the anti-B7-H4 ADC, specifically the ADC hu2F7-Exatecan (compound 34). This compound demonstrated antitumor activity ...
T11532 H4R antagonist 1 Histamine Receptor
H4R antagonist 1 is a highly selective histamine H4 receptor (H4R) antagonist (IC50: 27 nM). H4R antagonist 1 does not show any noticeable binding affinity to other subtypes of histamine receptors, H1R, H2R, and H3R.
T15565 Imetit dihydrobromide VUF 8325 dihydrobromide,SKF 91105 dihydrobromide Histamine Receptor
Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM).
T62460 INCB38579
INCB38579 is a selective, orally active, histamine H4 receptor (HH4R) antagonist that crosses the blood-brain barrier and acts on hH4R (IC50: 4.8 nM), mH4R (IC50: 42 nM), and rH4R (IC50: 32 nM). INCB38579 has anti-inflam...
T39073 Amredobresib
Amredobresib is a potent BET inhibitor that impedes the interaction between bromodomains and acetylated lysines on histone H3 and H4, thereby serving as crucial regulators of gene transcription. It proves valuable in the...
T73352 A-943931
A-943931, a selective and potent antagonist of the histamine H4 receptor (H4R), demonstrates affinity with pKi values of 4.6 and 3.8 nM for human and rat H4Rs, respectively. This compound exhibits anti-inflammatory and a...
T35003 UR-PI376 UR-PI 376,UR-PI-376,URPI-376,URPI 376
UR-PI376 is a histamine H4 receptor agonist (hH4R agonist) (pEC50 = 7.47, alpha = 0.93), with low activity for hH1R and hH2R and significant selectivity for hH3R (pKB = 6.00, alpha =- 0.28), as in stable-use a membrane p...
T61011 Izuforant
Izuforant (JW1601) (Compound 24) has potent anti-inflammatory and anti-pruritic activities. Izuforant has a binding affinity for human serotonin 3 receptor (h5-HT3R) with an IC50 value of 9.1 μM. Izuforant is also an ora...
T35818 CAY10669
CAY10669 is an inhibitor of the histone acetyltransferase PCAF (p300/CREB-binding protein-associated factor; IC50 = 662 μM), displaying a 2-fold improvement in inhibitory potency over anacardic acid . At 30-60 μM, CAY106...
T79786 H4R antagonist 2 Histamine Receptor
H4R Antagonist 2, a potent Furo[3,2-d]pyrimidine derivative, serves as a histamine H4 receptor antagonist and holds potential for research into rheumatoid arthritis [1] (page 68).
T61552 ATG7-IN-3
ATG7-IN-3 (compound 18) is an effective inhibitor of ATG7, with a potency of 0.048 μM as determined by its IC50 value. It exhibits inhibitory actions on autophagy. Moreover, ATG7-IN-3 effectively hampers the development ...
T30304 BAY-850 HCl BAY-850,BAY850,BAY 850
BAY-850 is a chemical probe for the bromine domain of Atad2A. It replaces acetylated H4 peptides from the bromine domain of Atad2. AY-850 shows superior selectivity to all other bromine domains (not hit in 10 μm Bromosca...
T28114 MS2177 MS 2177,MS-2177
MS2177 is a potent and selective inhibitor of SETD8, the only methyltransferase known to catalyze monomethylation of histone H4 lysine 20 (H4K20). MS2177 has an in vitro IC50 of 1.9 μM (σ = 1.05 μM, n = 4) in ascintillat...
T35825 Trichostatin C
Trichostatin C is a glycosylated derivative of trichostatin A , the antifungal antibiotic that reversibly inhibits histone deacetylase. Trichostatin C is reported to be the first example of a glucopyranosyl hydroxamate i...
T79710 PI3Kα/HDAC6-IN-1 HDAC
PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively. It effectively hinders AKT(Ser473) phosphorylation and promotes the build-up of acetylated...
T38323 A-943931 (hydrochloride hydrate)
A-943931 is a histamine H4receptor antagonist (Ki= 3.8 nM).1In vivo, A-943931 inhibits scratching induced by clobenpropit in mice (ED50= 26 μmoles/kg, i.p.). 1.Milicic, I., Witte, D.G., Miller, T.L., et al.Identification...

Compounds

Leucomycin a5
T32669
Synonym: Leukomycin A5,Turimycin H4
Target:
H4 Receptor antagonist 1
T5829
Synonym:
Target: Histamine Receptor
VUF10460
T3963
Synonym:
Target: Histamine Receptor
JNJ-39758979
T11723L
Synonym:
Target: Histamine Receptor
ST-1006
T34709
Synonym: ST 1006
Target: Histamine Receptor
Scriptaid
T6980
Synonym: GCK1026,Scriptide
Target: Apoptosis, Influenza Virus, HDAC, Autophagy
Crebinostat
T27083
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase, HDAC
1-Naphthohydroxamic acid
T13996
Synonym:
Target: HDAC
Clobenpropit dihydrobromide
T8439
Synonym:
Target: Apoptosis, Histamine Receptor
Histamine H4 receptor antagonist-1
T38634
Synonym: Histamine H4 receptor antagonist-1
Target:
Seliforant
T28746
Synonym:
Target:
Adriforant
T68280
Synonym:
Target:
VUF 8430
T29146
Synonym: VUF8430,VUF-8430
Target:
OUP-16
T33831
Synonym: OUP 16,OUP16
Target:
Alsevalimab
T78287
Synonym:
Target:
A-940894
T23597
Synonym: A940894,A 940894
Target:
UR-RG98
T35004
Synonym: UR-RG 98,URRG 98,URRG98,URRG-98,UR-RG-98
Target:
Epigenetic Multiple Ligand
T72013
Synonym:
Target:
VUF-10497
T24951
Synonym:
Target:
AC-93253 iodide
T24998
Synonym: AC93253 iodide
Target:
A 987306
T22018
Synonym:
Target:
Puxitatug
T81345
Synonym:
Target:
JNJ-28610244
T24207
Synonym: JNJ 28610244
Target:
JNJ-10191584
T27658
Synonym: VUF-6002,JNJ10191584
Target:
Histone H4 (2-21)
TP1536
Synonym:
Target:
Adriforant tartrate hydrate
T69918
Synonym:
Target:
Gly-Cyclopropane-Exatecan
T74735
Synonym:
Target:
H4R antagonist 1
T11532
Synonym:
Target: Histamine Receptor
Imetit dihydrobromide
T15565
Synonym: VUF 8325 dihydrobromide,SKF 91105 dihydrobromide
Target: Histamine Receptor
INCB38579
T62460
Synonym:
Target:
Amredobresib
T39073
Synonym:
Target:
A-943931
T73352
Synonym:
Target:
UR-PI376
T35003
Synonym: UR-PI 376,UR-PI-376,URPI-376,URPI 376
Target:
Izuforant
T61011
Synonym:
Target:
CAY10669
T35818
Synonym:
Target:
H4R antagonist 2
T79786
Synonym:
Target: Histamine Receptor
ATG7-IN-3
T61552
Synonym:
Target:
BAY-850 HCl
T30304
Synonym: BAY-850,BAY850,BAY 850
Target:
MS2177
T28114
Synonym: MS 2177,MS-2177
Target:
Trichostatin C
T35825
Synonym:
Target:
PI3Kα/HDAC6-IN-1
T79710
Synonym:
Target: HDAC
A-943931 (hydrochloride hydrate)
T38323
Synonym:
Target:
Cat No. Product Name Synonyms Targets
TN1724 Harmalol hydrochloride Harmidol hydrochloride P450 , Antioxidant
Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is the major metabolite of Harmaline and significantly inhibits ...
TN5359 Ustusol H4 Drima-6,8(12)-diene-9α,11-diol
Ustusol H4 is a natural product for research related to life sciences. The catalog number is TN5359 and the CAS number is 2193060-25-0.
T83274 6′-Galactosyllactose
6′-Galactosyllactose, a predominant oligosaccharide in human milk, is instrumental in synthesizing human milk oligosaccharides, including 3′-Galactosyllactose and 4′-Galactosyllactose. This compound has been shown to mit...
T80349 Maximin H4
Maximin H4, an antimicrobial peptide originating from the skin secretions of the Chinese red belly toad (Bombina maxima), exhibits inhibitory activity against a spectrum of microorganisms, including Escherichia coli (ATC...

Natural Products

Harmalol hydrochloride
TN1724
Synonym: Harmidol hydrochloride
Target: P450, Antioxidant
Ustusol H4
TN5359
Synonym: Drima-6,8(12)-diene-9α,11-diol
Target:
6′-Galactosyllactose
T83274
Synonym:
Target:
Maximin H4
T80349
Synonym:
Target:

Recombinant Proteins

Species：
Human (151)
Human & Mouse (4)
Arabidopsis thaliana (1)
E. coli (1)
Human,Mouse (1)
Expression System：
HEK293 Cells (127)
E. coli (28)
Baculovirus Insect Cells (2)
P. pastoris (Yeast) (1)
Tag：
C-His-Avi (139)
N-His (4)
Tag Free (4)
C-His (2)
N-6xHis (2)
N-GST (2)
C-hFc-Avi (1)
His, GST (1)
N-10xHis (1)
N-10xHis, C-Myc (1)
Cat No. Product Name Species Expression System
TMPY-04092 Histone H4 Protein, Human, Recombinant Human E. coli
Histone H4 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11.4 kDa and the accession number is B2R4R0.
TMPY-02521 HIST3H2A Protein, Human, Recombinant Human E. coli
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident ...
TMPH-03748 KAT14 Protein, Human, Recombinant (His) Human E. coli
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltrans...
TMPK-00172 B7-H4 Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
B7-H4, also known as B7x and B7S1, is a 50-80 kDa glycosylated member of the B7 family of immunomodulatory proteins.B7-H4 is up-regulated in several carcinomas in correlation with tumor progression and metastasis. A solu...
TMPJ-00176 B7-H4 Protein, Human, Recombinant (hFc & Avi), Biotinylated Human HEK293 Cells
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H4 consists of a 235 amino acid (aa) extracellular domain (ECD) with two Ig-like V-type domains, a 21 aa tra...
TMPY-03498 ING4 Protein, Human, Recombinant (His) Human E. coli
ING4 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. ING4 contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling...
TMPY-01657 SUV420H2 Protein, Human, Recombinant (His & GST) Human E. coli
Histone-lysine N-methyltransferase SUV42H2, also known as Suppressor of variegation 4-2 homolog 2, Su(var)4-2 homolog 2, Lysine N-methyltransferase 5C, SUV42H2 and KMT5C, is nucleus protein that belongs to the histone-ly...
TMPH-01472 HDAC11 Protein, Human, Recombinant (GST) Human E. coli
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcrip...
TMPY-02447 Shiga toxin II subunit B Protein, E. coli, Recombinant (His) E. coli E. coli
E. Coli STX2B is a subunit of Stx2. Stx2, together with Stx1, formed a family of related toxins which are known as shiga toxins. Shiga toxins are mainly produced by the bacteria S. dysenteriae and the Shigatoxigenic grou...
TMPJ-01353 MBIPP Protein, Human, Recombinant (His) Human E. coli
MAP3K12-binding inhibitory protein 1 (MBIP) is a 39kD protein high expression in the heart and lung. It is a component of the ADA2A-containing complex (ATAC) complex, a complex with histone acetyltransferase activity on ...
TMPH-00095 HDT2 Protein, Arabidopsis thaliana, Recombinant (His) Arabidopsis thaliana P. pastoris (Yeast)
Probably mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcr...
TMPY-02981 ING5 Protein, Human, Recombinant (GST) Human E. coli
ING5 belongs to the ING family. It contains 1 PHD-type zinc finger and is a component of the HBO1 complex. HBO1 complex has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is re...
TMPY-03263 RUVBL1 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
RUVBL1, also known as RVB1, is a component of the NuA4 histone acetyltransferase complex and belongs to the RuvB family. RUVBL1 is ubiquitously expressed with high expression in heart, skeletal muscle and testis. It poss...
TMPY-03341 ASF1B Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
The histone chaperone anti-silencing factor 1a (ASF1a) interacts with MDC1 and is recruited to sites of DSBs to facilitate the interaction of phospho-ATM with MDC1 and phosphorylation of MDC1, which are required for the ...
TMPY-01332 HIST1H3A Protein, Human, Mouse, Recombinant Human,Mouse E. coli
Histone H3.1, also known as HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, is a member of the histone H3 family which is a core component of nucleosome. It is expresse...
TMPY-01869 SIRT1 Protein, Human, Recombinant (His) Human E. coli
SIRT1 belongs to the sirtuin family. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT1 is included in class I of the sirtuin family. It is a NAD-dependent prote...
TMPY-02510 HIST2H2BE Protein, Human, Recombinant Human E. coli
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. Histone proteins exhibit two levels of diversity: 1. evolutionary diversity between species and...
TMPH-01267 RNF13 Protein, Human, Recombinant (His & Myc) Human E. coli
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair protein...
TMPK-01422 Peptide Ready HLA-A*02:01&B2M Monomer Protein, Human, MHC (His & Avi) Human HEK293 Cells
Peptide Ready HLA-A*02:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M,...
TMPK-01415 APC-equivalent Peptide Ready HLA-A*02:01&B2M Tetramer Protein, Human, MHC (His) Human HEK293 Cells
Peptide Ready HLA-A*02:01&B2M Tetramer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M...
TMPK-01421 Peptide Ready HLA-A*02:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated Human HEK293 Cells
HLA-A*02:01&B2M&Peptide ready Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M,...
TMPK-01419 Peptide Ready HLA-A*03:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated Human HEK293 Cells
Peptide Ready HLA-A*03:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*03:01. Peptide ready MHC molecules comprising human HLA alleles and B2M,...
TMPK-01425 Peptide Ready HLA-A*11:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated Human HEK293 Cells
Peptide Ready HLA-A*11:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*11:01. Peptide ready MHC molecules comprising human HLA alleles and B2M,...
TMPK-01426 Peptide Ready HLA-A*11:01&B2M Monomer Protein, Human, MHC (His & Avi) Human HEK293 Cells
Peptide Ready HLA-A*11:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*11:01. Peptide ready MHC molecules comprising human HLA alleles and B2M,...
TMPK-01409 Peptide Ready HLA-A*24:02&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated Human HEK293 Cells
Peptide Ready HLA-G&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-G. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can b...
TMPK-01455 HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Monomer Protein, Human, MHC (His & Avi) Human HEK293 Cells
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumor...
TMPK-01406 HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled Human HEK293 Cells
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumor...
TMPK-01432 HLA-A*11:01&B2M&KRAS G12A (VVVGAAGVGK) Tetramer Protein, Human, MHC (His & Avi) Human HEK293 Cells
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr...
TMPK-01445 HLA-A*02:01&B2M&MAGE-A1 (KVLEYVIKV) Monomer Protein, Human, MHC (His & Avi), Biotinylated Human HEK293 Cells
MAGE-A1 belongs to the chromosome X-clustered genes of cancer-testis antigen family and is normally expressed in the human germ line but is also overexpressed in various tumors.
TMPK-01468 HLA-A*02:01&B2M&MART-1 (ELAGIGILTV) Tetramer Protein, Human, MHC (His & Avi) Human HEK293 Cells
Melanoma antigen recognized by T cell-1 (Mart-1), one of the melanosome-specific proteins, also recognized by cytotoxicity T lymphocytes as a marker. Mart-1 is considered to play a critical role in the immunotherapy for ...
TMPK-01459 HLA-A*02:01&B2M&MAGE-A4 or MAGE-A8 (KVLEHVVRV) Monomer Protein, Human, MHC (His & Avi), Biotinylated Human HEK293 Cells
MAGE-A4 and MAGE-A8 are type I membes of the melanoma associated antigen (MAGE) family. The MAGE family is a large, highly conserved group of proteins that share a common MAGE homology domain. Both MAGE-A4 and MAGE-A8 an...
TMPK-01495 HLA-A*01:01&B2M&MAGE-A3 (EVDPIGHLY) Monomer Protein, Human, MHC (His & Avi) Human HEK293 Cells
Melanoma antigen gene A3 (MAGE-A3) is one of the most immunogenic cancer testis antigens and is common in various types of cancers. MAGE-A3 can be considered as a predictor for poor prognosis and an option for vaccine im...
TMPK-01433 HLA-A*11:01&B2M&KRAS G12C (VVVGACGVGK) Tetramer Protein, Human, MHC (His & Avi) Human HEK293 Cells
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr...
TMPK-01482 HLA-A*02:03&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi) Human HEK293 Cells
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple ...
TMPK-01496 HLA-A*01:01&B2M&CT83 (NTDNNLAVY) Monomer Protein, Human, MHC (His & Avi) Human HEK293 Cells
Cancer/testis antigens 83 (CT83), also called KK-LC-1 or CXorf61, recognized by cytotoxic T lymphocytes (CTL), has become a promising target for immunotherapy.
TMPK-01530 HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human, MHC (His & Avi), Biotinylated Human HEK293 Cells
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that sel...
TMPK-01519 HLA-A*02:01&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi) Human HEK293 Cells
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple ...
TMPK-01532 HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer Protein, Human, MHC (His & Avi) Human HEK293 Cells
p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell prolifer...
TMPK-01515 HLA-A*02:01&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi) Human HEK293 Cells
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple ...
TMPK-01498 HLA-A*11:01&B2M&LMP2 (SSCSSCPLTK) Tetramer Protein, Human, MHC (His & Avi) Human HEK293 Cells
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that sel...
TMPK-01428 HLA-A*11:01&B2M&KRAS G12D (VVGADGVGK) Monomer Protein, Human, MHC (His & Avi) Human E. coli
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr...
TMPK-01449 HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (E. coli, His & Avi) Human E. coli
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,...
TMPK-01404 HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Monomer Protein, Human, MHC (E. coli, His & Avi), Biotinylated Human E. coli
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr...
TMPK-01526 HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein, Human, MHC (His & Avi) Human HEK293 Cells
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr...
TMPK-01453 HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated Human HEK293 Cells
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr...
TMPK-01457 HLA-A*11:01&B2M&KRAS G12A (VVVGAAGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated Human HEK293 Cells
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr...
TMPK-01447 HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Monomer Protein, Human, MHC (His & Avi), Biotinylated Human HEK293 Cells
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumor...
TMPK-01461 HLA-A*11:01&B2M&KRAS G12S (VVVGASGVGK) Monomer Protein, Human, MHC (His & Avi) Human HEK293 Cells
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr...
TMPK-01500 HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi) Human HEK293 Cells
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,...
TMPK-01517 HLA-A*02:01&B2M&Survivin (LMLGEFLKL) Monomer Protein, Human, MHC (His & Avi) Human HEK293 Cells
Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upreg...
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Histone H4 Protein, Human, Recombinant
TMPY-04092
Species: Human
Expression System: E. coli
HIST3H2A Protein, Human, Recombinant
TMPY-02521
Species: Human
Expression System: E. coli
KAT14 Protein, Human, Recombinant (His)
TMPH-03748
Species: Human
Expression System: E. coli
B7-H4 Protein, Human, Recombinant (His & Avi)
TMPK-00172
Species: Human
Expression System: HEK293 Cells
B7-H4 Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPJ-00176
Species: Human
Expression System: HEK293 Cells
ING4 Protein, Human, Recombinant (His)
TMPY-03498
Species: Human
Expression System: E. coli
SUV420H2 Protein, Human, Recombinant (His & GST)
TMPY-01657
Species: Human
Expression System: E. coli
HDAC11 Protein, Human, Recombinant (GST)
TMPH-01472
Species: Human
Expression System: E. coli
Shiga toxin II subunit B Protein, E. coli, Recombinant (His)
TMPY-02447
Species: E. coli
Expression System: E. coli
MBIPP Protein, Human, Recombinant (His)
TMPJ-01353
Species: Human
Expression System: E. coli
HDT2 Protein, Arabidopsis thaliana, Recombinant (His)
TMPH-00095
Species: Arabidopsis thaliana
Expression System: P. pastoris (Yeast)
ING5 Protein, Human, Recombinant (GST)
TMPY-02981
Species: Human
Expression System: E. coli
RUVBL1 Protein, Human, Recombinant (His)
TMPY-03263
Species: Human
Expression System: Baculovirus Insect Cells
ASF1B Protein, Human, Recombinant (His)
TMPY-03341
Species: Human
Expression System: Baculovirus Insect Cells
HIST1H3A Protein, Human, Mouse, Recombinant
TMPY-01332
Species: Human,Mouse
Expression System: E. coli
SIRT1 Protein, Human, Recombinant (His)
TMPY-01869
Species: Human
Expression System: E. coli
HIST2H2BE Protein, Human, Recombinant
TMPY-02510
Species: Human
Expression System: E. coli
RNF13 Protein, Human, Recombinant (His & Myc)
TMPH-01267
Species: Human
Expression System: E. coli
Peptide Ready HLA-A*02:01&B2M Monomer Protein, Human, MHC (His & Avi)
TMPK-01422
Species: Human
Expression System: HEK293 Cells
APC-equivalent Peptide Ready HLA-A*02:01&B2M Tetramer Protein, Human, MHC (His)
TMPK-01415
Species: Human
Expression System: HEK293 Cells
Peptide Ready HLA-A*02:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated
TMPK-01421
Species: Human
Expression System: HEK293 Cells
Peptide Ready HLA-A*03:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated
TMPK-01419
Species: Human
Expression System: HEK293 Cells
Peptide Ready HLA-A*11:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated
TMPK-01425
Species: Human
Expression System: HEK293 Cells
Peptide Ready HLA-A*11:01&B2M Monomer Protein, Human, MHC (His & Avi)
TMPK-01426
Species: Human
Expression System: HEK293 Cells
Peptide Ready HLA-A*24:02&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated
TMPK-01409
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Monomer Protein, Human, MHC (His & Avi)
TMPK-01455
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
TMPK-01406
Species: Human
Expression System: HEK293 Cells
HLA-A*11:01&B2M&KRAS G12A (VVVGAAGVGK) Tetramer Protein, Human, MHC (His & Avi)
TMPK-01432
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&MAGE-A1 (KVLEYVIKV) Monomer Protein, Human, MHC (His & Avi), Biotinylated
TMPK-01445
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&MART-1 (ELAGIGILTV) Tetramer Protein, Human, MHC (His & Avi)
TMPK-01468
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&MAGE-A4 or MAGE-A8 (KVLEHVVRV) Monomer Protein, Human, MHC (His & Avi), Biotinylated
TMPK-01459
Species: Human
Expression System: HEK293 Cells
HLA-A*01:01&B2M&MAGE-A3 (EVDPIGHLY) Monomer Protein, Human, MHC (His & Avi)
TMPK-01495
Species: Human
Expression System: HEK293 Cells
HLA-A*11:01&B2M&KRAS G12C (VVVGACGVGK) Tetramer Protein, Human, MHC (His & Avi)
TMPK-01433
Species: Human
Expression System: HEK293 Cells
HLA-A*02:03&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi)
TMPK-01482
Species: Human
Expression System: HEK293 Cells
HLA-A*01:01&B2M&CT83 (NTDNNLAVY) Monomer Protein, Human, MHC (His & Avi)
TMPK-01496
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human, MHC (His & Avi), Biotinylated
TMPK-01530
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi)
TMPK-01519
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer Protein, Human, MHC (His & Avi)
TMPK-01532
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi)
TMPK-01515
Species: Human
Expression System: HEK293 Cells
HLA-A*11:01&B2M&LMP2 (SSCSSCPLTK) Tetramer Protein, Human, MHC (His & Avi)
TMPK-01498
Species: Human
Expression System: HEK293 Cells
HLA-A*11:01&B2M&KRAS G12D (VVGADGVGK) Monomer Protein, Human, MHC (His & Avi)
TMPK-01428
Species: Human
Expression System: E. coli
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (E. coli, His & Avi)
TMPK-01449
Species: Human
Expression System: E. coli
HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Monomer Protein, Human, MHC (E. coli, His & Avi), Biotinylated
TMPK-01404
Species: Human
Expression System: E. coli
HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein, Human, MHC (His & Avi)
TMPK-01526
Species: Human
Expression System: HEK293 Cells
HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated
TMPK-01453
Species: Human
Expression System: HEK293 Cells
HLA-A*11:01&B2M&KRAS G12A (VVVGAAGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated
TMPK-01457
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Monomer Protein, Human, MHC (His & Avi), Biotinylated
TMPK-01447
Species: Human
Expression System: HEK293 Cells
HLA-A*11:01&B2M&KRAS G12S (VVVGASGVGK) Monomer Protein, Human, MHC (His & Avi)
TMPK-01461
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi)
TMPK-01500
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&Survivin (LMLGEFLKL) Monomer Protein, Human, MHC (His & Avi)
TMPK-01517
Species: Human
Expression System: HEK293 Cells
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Cat No. Product Name
L3510 Methylation Compound Library

128 compounds
128 methylation-related compounds that can be used for high-throughput and high-content screening.

Libraries

Methylation Compound Library
L3510
Compounds: 128
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