Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VUF10460 is a non-imidazole histamine H4 receptor agonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 32.00 | |
5 mg | In stock | $ 52.00 | |
10 mg | In stock | $ 85.00 | |
25 mg | In stock | $ 166.00 | |
50 mg | In stock | $ 288.00 | |
100 mg | In stock | $ 450.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 57.00 |
Description | VUF10460 is a non-imidazole histamine H4 receptor agonist. |
Targets&IC50 | H4 receptor:7.46(pKi) |
In vitro | UF10460 binds to rat H3 and H4 receptor with pKi values of 5.75, and 7.46, respectively, whereas VUF10460 displays approximately a 50-fold selectivity for the rat H4 receptor over the H3 receptor[1]. |
In vivo | HCl-induced rat gastric lesions is significantly enhanced by the H4 receptor agonists VUF10460. This effect is not modified by H4 receptor antagonist JNJ7777120[1]. VUF10460 displayed approximately a 50-fold selectivity for the rat H(4) receptor over the H(3) receptor. |
Molecular Weight | 269.34 |
Formula | C15H19N5 |
CAS No. | 1028327-66-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 36 mg/mL
You can also refer to dose conversion for different animals. More
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VUF10460 1028327-66-3 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor Inhibitor VUF 10460 inhibit VUF-10460 inhibitor