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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T0251 | Gemcitabine | NSC 613327,LY188011 | Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis , Autophagy |
Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis. | |||
T6069 | Gemcitabine hydrochloride | Gemcitabine HCl,Gemzar,LY188011,LY 188011 hydrochloride | Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis , Autophagy |
Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy a... | |||
T15378L | Gemcitabine elaidate hydrochloride | CO-101 hydrochloride,Gemcitabine elaidate hydrochloride(210829-30-4(free base)),Gemcitabine 5'-elaidate hydrochloride,CP-4126 hydrochloride | Others |
Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-drug of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. In contrast to gemcitabine, G... | |||
T15378 | Gemcitabine elaidate | Gemcitabine 5'-elaidate,Gemcitabine (elaidate),CO-101,CP-4126 | Apoptosis , Nucleoside Antimetabolite/Analog , Autophagy |
Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracel... | |||
T21329 | Gemcitabine monophosphate disodium salt | Gemcitabine monophosphate disodium salt monohydrate,Gemcitabine monophosphate disodium,GemMP | |
R306465 is a novel HDAC inhibitor with broad-spectrum antitumor activity against solid (IC50: 30 to 300 nM) and hematological malignancies. R306465 was found to be a potent inhibitor of HDAC1 and -8 (class I) in vitro. | |||
T4187 | Gemcitabine monophosphate sodium salt hydrate | Others , DNA , DNA/RNA Synthesis , Autophagy | |
Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine. | |||
T75252 | Gemcitabine triphosphate | ||
Gemcitabine triphosphate (dFdCTP), alongside its counterpart, the active diphosphate (dFdCDP), represents one of the two primary nucleoside metabolites of Gemcitabine within cellular structures. It serves as a benchmark ... | |||
T17985 | Gemcitabine-O-Si(di-iso)-O-Mc | Others | |
Gemcitabine-O-Si(di-iso)-O-Mc, a drug-linker conjugate for Antibody-Drug Conjugates (ADC), exhibits potent antitumor activity. It incorporates Gemcitabine, a pyrimidine nucleoside analog antimetabolite and antineoplastic... | |||
T4061 | LY2334737 | Nucleoside Antimetabolite/Analog , Others , Virus Protease | |
LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity. | |||
T6028 | PF 477736 | PF 00477736,PF-477736,PF-736,PF-00477736,PF477736 | c-Fms , VEGFR , FGFR , FLT , c-RET , Chk , CDK , Src , Aurora Kinase |
PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes. | |||
T4060 | Acelarin | NUC-1031 | DNA/RNA Synthesis |
Acelarin (NUC-1031) (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine. | |||
T67291 | 2′,2′-Difluorodeoxyuridine | dFdU,2',2'-Difluoro-2'-deoxyuridine | Drug Metabolite |
2′,2′-Difluorodeoxyuridine (dFdU) is the major metabolite of Gemcitabine.2′,2′-Difluorodeoxyuridine has anticancer and antitumor activity, and shows radiosensitization under hypoxic conditions, and can be used to study p... | |||
T41345 | AFMK | Formyl-N-acetyl-5-methoxykynurenamine,Acetyl-N-formyl-5-methoxykynurenamine | Apoptosis , Free radical scavengers , Antioxidant , Endogenous Metabolite |
AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity. AFMK is a modulator of apoptosis and improves the anti-tumor effect of Gemcitabine ... | |||
T16813 | RX-3117 | fluorocyclopentenylcytosine,TV-1360 | Nucleoside Antimetabolite/Analog |
RX-3117 (fluorocyclopentenylcytosine) is a novel a cytidine analog. RX-3117 displays anticancer activity in several cancer cell lines, including gemcitabine-resistant variants. | |||
T4126 | CBL0137 | Curaxin 137,CBLC137 | NF-κB , p53 |
CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the eff... | |||
T71259 | GNE-900 | GNE900,GNE 900 | Apoptosis , Chk |
GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 ... | |||
T19779 | SL-01 | Z L Phe chloromethyl ketone,NSC-251810,ZLPhe chloromethyl ketone,Z-Phe-chloromethylketone | |
SL-01 is an oral derivative of gemcitabine. SL-01 inhibited human breast cancer growth through the induction of apoptosis. SL-01 inhibited human cancer growth more potently than gemcitabine. | |||
T79198 | S-Gem | Nucleoside Antimetabolite/Analog | |
S-Gem, a thioredoxin reductase (TrxR)-dependent prodrug of Gemcitabine, is selectively activated by TrxR. Studies indicate that S-Gem exhibits lower cytotoxicity than Gemcitabine [1]. | |||
T17175 | Troxacitabine | BCH-4556,SGX-145,SGX145,SPD-758,BCH4556,beta-L-OddC | Others |
Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious ... | |||
T18313 | Mc-O-Si(di-iso)-Cl | Others | |
Mc-O-Si(di-iso)-Cl is a cleavable ADC linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs) like Gemcitabine-O-Si(di-iso)-O-Mc [1]. |