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SL-01

Catalog No. T19779 CAS 26049-94-5

Synonyms: Z L Phe chloromethyl ketone, NSC-251810, ZLPhe chloromethyl ketone, Z-Phe-chloromethylketone

SL-01 is an oral derivative of gemcitabine. SL-01 inhibited human breast cancer growth through the induction of apoptosis. SL-01 inhibited human cancer growth more potently than gemcitabine.

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SL-01, CAS 26049-94-5

Pack Size	Availability	Price/USD
250 mg	35 days	$ 93.00
500 mg	35 days	$ 170.00
1 g	35 days	$ 233.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

SL-01 is an oral derivative of gemcitabine. SL-01 inhibited human breast cancer growth through the induction of apoptosis. SL-01 inhibited human cancer growth more potently than gemcitabine.

Synonyms	Z L Phe chloromethyl ketone, NSC-251810, ZLPhe chloromethyl ketone, Z-Phe-chloromethylketone
Molecular Weight	331.79
Formula	C18H18ClNO3
CAS No.	26049-94-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Zhao C, Li Y, Qin Y, Wang R, Li G, Sun C, Qu X, Li W. Pharmacokinetics and metabolism of SL-01, a prodrug of gemcitabine, in rats. Cancer Chemother Pharmacol. 2013 Jun;71(6):1541-50. doi: 10.1007/s00280-013-2153-6. Epub 2013 Apr 6. PubMed PMID: 23564376. 2. Li YY, Qin YZ, Wang RQ, Li WB, Qu XJ. SL-01, an oral derivative of gemcitabine, inhibited human breast cancer growth through induction of apoptosis. Biochem Biophys Res Commun. 2013 Aug 23;438(2):402-9. doi: 10.1016/j.bbrc.2013.07.087. Epub 2013 Jul 27. PubMed PMID: 23899521. 3. Zhao C, Yue B, Liu H, Sun C, Li W, Qu X. SL-01, an oral gemcitabine derivative, inhibited human cancer growth more potently than gemcitabine. Toxicol Appl Pharmacol. 2012 Aug 1;262(3):293-300. doi: 10.1016/j.taap.2012.05.006. Epub 2012 May 19. PubMed PMID: 22617428. 4. Baptista CJ, Dourado I, de Andrade TM, Brignol S, Bertoni N, Bastos FI; Brazilian Multicity Study Group on Drug Misuse. HIV Prevalence, Knowledge, Attitudes, and Practices Among Polydrug Users in Brazil: A Biological Survey Using Respondent Driven Sampling. AIDS Behav. 2017 May 31. doi: 10.1007/s10461-017-1812-8. [Epub ahead of print] PubMed PMID: 28567550.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SL-01 26049-94-5 NSC251810 Z L Phe chloromethyl ketone NSC-251810 SL01 SL 01 NSC 251810 ZLPhe chloromethyl ketone Z-Phe-chloromethylketone inhibitor inhibit

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