gsk-b — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T27500	GSK-B
	GSK-B, a potent γ-secretase modulator, decreases Aβ42, increases Aβ38 with no effect on Aβ40 levels.
T17225	Vercirnon	CCX282-B,GSK-1605786,Traficet-EN	CCR
	Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.		CCR
T5540	GSK8612		IκB/IKK
	GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .		IκB/IKK
T6285	GSK-690693	GSK690693	Serine Protease , Akt , PKC , AMPK , Autophagy
	GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.		Serine Protease , Akt , PKC , AMPK , Autophagy
T6849	Uprosertib	GSK2141795,GSK795	Akt
	Uprosertib (GSK2141795) (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2.		Akt
T1911	Afuresertib	GSK2110183C,GSK2110183	ROCK , Akt , PKC
	Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.		ROCK , Akt , PKC
T7885	Afuresertib hydrochloride		ROCK , Akt , PKC
	Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)		ROCK , Akt , PKC
T70999	Aspafilioside B
	Aspafilioside B is a steroidal saponin extracted from Asparagus filicinus that inhibits the growth and proliferation of HCC cell lines.
T7426	ALSTERPAULLONE		Apoptosis , GSK-3 , CDK
	Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec		Apoptosis , GSK-3 , CDK
T6129	GSK-1070916	GSK-1070916A,GSK1070916	Apoptosis , Tie-2 , FLT , AMPK , Aurora Kinase
	GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1.		Apoptosis , Tie-2 , FLT , AMPK , Aurora Kinase
T2315	GSK-LSD1 dihydrochloride	GSK-LSD1 (hydrochloride),GSK-LSD1 2HCl	Histone Demethylase
	GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, ...		Histone Demethylase
T6358	1-Azakenpaullone	azakenpaullone	GSK-3
	1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.		GSK-3
T67748	ROCK-IN-5		ROCK , ERK
	ROCK-IN-5 (compound I-B-37) is a potent inhibitor of protein kinases, including ROCK, ERK, GSK, and AGC. ROCK-IN-5 exhibits the potential for cardiac, proliferative and neurodegenerative diseases research.		ROCK , ERK
T6169	Indirubin	Indigopurpurin,Indigo red,NSC 105327,Couroupitine B	Apoptosis , Raf , GSK-3 , CDK
	Indirubin (Couroupitine B) is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 uM and 0.6 uM.		Apoptosis , Raf , GSK-3 , CDK
T22341	GSK-114		Others
	GSK-114, a selective inhibitor of TNNI3 Interacting Kinase (TNNI3K) with IC50 of 25 nM, shows significant bias for TNNI3K over B-Raf with IC50 of 1000 nM, exceptional broad spectrum kinase selectivity and adequate oral e...		Others
T6787	BIO-acetoxime	BIA,GSK-3 Inhibitor X	Apoptosis , GSK-3 , HSV
	BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.		Apoptosis , GSK-3 , HSV
T6187	TDZD-8	GSK-3β Inhibitor I,NP 01139	GSK-3
	TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.		GSK-3
T6458	CYC-116		VEGFR , FLT , CDK , S6 Kinase , Aurora Kinase
	CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 ...		VEGFR , FLT , CDK , S6 Kinase , Aurora Kinase
T2247	KenPaullone	9-Bromopaullone,NSC-664704	GSK-3 , CDK
	KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp...		GSK-3 , CDK
T24734	RP-106	RP 106
	RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3.