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GSK-LSD1 dihydrochloride

Name: GSK-LSD1 dihydrochloride
Brand: TargetMol
SKU: T2315
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T2315Cas No. 2102933-95-7

Alias GSK-LSD1 2HCl, GSK-LSD1 (hydrochloride)

GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, MAO-B).

GSK-LSD1 dihydrochloride

🥰Excellent

Purity: 98.72%

Catalog No. T2315Alias GSK-LSD1 2HCl, GSK-LSD1 (hydrochloride)Cas No. 2102933-95-7

Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$48	In Stock
5 mg	$65	In Stock
10 mg	$105	In Stock
25 mg	$221	In Stock
50 mg	$335	In Stock
100 mg	$549	In Stock
500 mg	$1,170	In Stock
1 mL x 10 mM (in DMSO)	$65	In Stock

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Batch Information

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Purity:98.72%

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COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, MAO-B).
Targets&IC50	LSD1:16 nM
In vitro	GSK-LSD1 induces gene expression changes in cancer cell lines with average EC50 of < 5 nM and inhibits cancer cell line growth with average EC50 of < 5 nM. [1]
Synonyms	GSK-LSD1 2HCl, GSK-LSD1 (hydrochloride)

Chemical Properties

Molecular Weight	289.24
Formula	C₁₄H₂₂Cl₂N₂
Cas No.	2102933-95-7
Smiles	Cl.Cl.C1[C@@H](NC2CCNCC2)[C@@H]1c1ccccc1
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (86.43 mM), Sonication is recommended.

H2O: 50 mg/mL (172.87 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.4573 mL	17.2867 mL	34.5734 mL	172.8668 mL
5 mM	0.6915 mL	3.4573 mL	6.9147 mL	34.5734 mL
10 mM	0.3457 mL	1.7287 mL	3.4573 mL	17.2867 mL
20 mM	0.1729 mL	0.8643 mL	1.7287 mL	8.6433 mL
50 mM	0.0691 mL	0.3457 mL	0.6915 mL	3.4573 mL

H2O

	1mg	5mg	10mg	50mg
100 mM	0.0346 mL	0.1729 mL	0.3457 mL	1.7287 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc