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Afuresertib hydrochloride

Catalog No. T7885 CAS 1047645-82-8

Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)

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Afuresertib hydrochloride Chemical Structure

Afuresertib hydrochloride, CAS 1047645-82-8

Pack Size	Availability	Price/USD
2 mg	In stock	$ 44.00
5 mg	In stock	$ 68.00
10 mg	In stock	$ 96.00
25 mg	In stock	$ 166.00
50 mg	In stock	$ 266.00
100 mg	In stock	$ 460.00
200 mg	In stock	$ 598.00
1 mL * 10 mM (in DMSO)	In stock	$ 78.00

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Purity: 100%

Biological Description

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Description	Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
Targets&IC50	Akt3:2.6 nM(Ki), Akt2:2 nM(Ki), Akt1:0.08 nM(Ki)
In vitro	Afuresertib-induced p21 expression promotes G1 phase arrest by inducing FOXO activity.?Furthermore, afuresertib significantly enhanced cisplatin-induced cytotoxicity.Afuresertib modulated the expression E2F1 and MYC, which are associated with fibroblast core serum response.?Suggest that afuresertib is a useful anticancer drug for treating patients with MPM[1].
Cell Research	Cell confluence proliferation assay was performed using Incucyte ZOOM Live‐Cell Imaging System.?Briefly, ACC‐MESO‐4 and MSTO‐211H cells were seeded in 12‐well plates (cell density, 1 × 104 cells/well) and were incubated for 24 h at 37°C.?Then, the cells were incubated with 0, 2, 5, or 10 μmol/L afuresertib.?During treatment, cell growth was monitored by recording phase images using the IncuCyte ZOOM Live‐Cell Imaging System (magnification, ×100)[1].

Molecular Weight	463.8
Formula	C18H18Cl3FN4OS
CAS No.	1047645-82-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (215.62 mM), Sonification is recommended.

References and Literature

1. Yamaji M , Ota A , Wahiduzzaman M , et al. Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells[J]. Cancer Medicine, 2017. 2. Blagden SP, Hamilton AL, Mileshkin L,et al.Phase IB Dose Escalation and Expansion Study of AKT Inhibitor Afuresertib with Carboplatin and Paclitaxel in Recurrent Platinum-resistant Ovarian Cancer.Clin Cancer Res. 2019 Mar 1;25(5):1472-1478.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library TGF-beta/Smad Compound Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Metabolism Compound Library Bioactive Compounds Library Max Oxidation-Reduction Compound Library Neural Regeneration Compound Library

Related Products

Related compounds with same targets

WAY-656935 ROCK-IN-2 RKI-1447 LX7101 ROCK-IN-9 Afuresertib Akt/ROCK-IN-1 H-1152 dihydrochloride

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Afuresertib hydrochloride 1047645-82-8 Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling PI3K/Akt/mTOR signaling Stem Cells PKC Akt ROCK Afuresertib Afuresertib Hydrochloride Protein kinase C PKB Rho-kinase GSK2110183 ROK Rho-associated protein kinase Inhibitor GSK-2110183 inhibit Protein kinase B Rho-associated kinase GSK 2110183 inhibitor

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