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GSK8612

Catalog No. T5540 CAS 2361659-62-1

GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .

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GSK8612, CAS 2361659-62-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 39.00
2 mg	In stock	$ 54.00
5 mg	In stock	$ 84.00
10 mg	In stock	$ 133.00
25 mg	In stock	$ 226.00
50 mg	In stock	$ 397.00
100 mg	In stock	$ 597.00
1 mL * 10 mM (in DMSO)	In stock	$ 97.00

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Purity: 99.8%

Purity: 99.46%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .
Targets&IC50	TBK1:6.8 (pIC50)
In vitro	In cellular assays, GSK8612 inhibited toll-like receptor (TLR)3-induced interferon regulatory factor (IRF)3 phosphorylation in Ramos cells and type I interferon (IFN) secretion in primary human mononuclear cells. In THP1 cells, GSK8612 was able to inhibit secretion of interferon-beta (IFNβ) in response to dsDNA and cGAMP, the natural ligand for STING.

Molecular Weight	520.33
Formula	C17H17BrF3N7O2S
CAS No.	2361659-62-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 100 mg/mL (192.19 mM)

References and Literature

1. Thomson DW, et al. Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor. ACS Med Chem Lett. 2019 Mar 11;10(5):780-785.

Related compound libraries

This product is contained In the following compound libraries：

Highly Selective Inhibitor Library Inhibitor Library Anti-Breast Cancer Compound Library HIF-1 Signaling Pathway Compound Library Kinase Inhibitor Library Anti-Cancer Compound Library NO PAINS Compound Library Immunology/Inflammation Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GSK8612 2361659-62-1 NF-Κb IκB/IKK Inhibitor GSK 8612 IKK I kappa B kinase GSK-8612 inhibit IκB kinase inhibitor

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