abcg2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T79513	ABCG2-IN-1		BCRP
	ABCG2-IN-1 (compound K2), an analog of Ko143, constitutes an orally active inhibitor targeting ABCG2 with an inhibitory concentration (IC50) of 0.13 μM. Demonstrating favorable oral pharmacokinetics in mice, ABCG2-IN-1 s...		BCRP
T79514	ABCG2-IN-2		BCRP
	ABCG2-IN-2 is a potent inhibitor of ABCG2, exhibiting favorable oral pharmacokinetic profiles in mice, and is applicable for investigating tumor multidrug resistance (MDR) and erythropoietic protoporphyria (EPP) [1].		BCRP
TQ0186	Ko 143		BCRP , ABC
	Ko 143 is a selective inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2; BCRP).		BCRP , ABC
T3581	KS176		Potassium Channel , BCRP
	KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter, showing no inhibitory activity against P-gp or MRP1.		Potassium Channel , BCRP
T4595	YHO-13177	YHO 13177,YHO13177	BCRP
	YHO-13177 is a potent and specific inhibitor of BCRP; potentiated the cytotoxicity of SN-38 in cancer cells and no effect on P-glycoprotein–mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells.		BCRP
T38400	Triclabendazole sulfoxide	TCBZ-SO	BCRP , Parasite
	Triclabendazole sulfoxide (TCBZ-SO) is a main plasma metabolite of Triclabendazole. Triclabendazole sulfoxide inhibits membrane transporter ABCG2/BCRP and exhibits anti-parasite effects.		BCRP , Parasite
T8596	Ceefourin 1		MRP
	Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.		MRP
T4337	PCI 29732	PCI29732,PCI-29732	Others , BCRP , BTK
	PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.		Others , BCRP , BTK
T13383	Zamicastat	BIA 5-1058	BCRP , Hydroxylase , P-gp
	Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively).		BCRP , Hydroxylase , P-gp
T8491	Vorolanib	CM082,X-82	VEGFR , PDGFR
	Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor.		VEGFR , PDGFR
T2657	Elacridar	GW0918,GW120918,GF120918,GG918	BCRP , P-gp
	Elacridar (GG918) (GF120918) is an effective BCRP and P-gp (MDR-1) inhibitor.		BCRP , P-gp
TN3150	6,8-Diprenylnaringenin	Senegalensin,Lonchocarpol A	BCRP , ABC
	6,8-Diprenylnaringenin (Senegalensin) is a natural product from hop Humulus lupulus. 6,8-Diprenylnaringenin is a breast cancer resistance protein(BCRP) inhibitor with some estrogenicity.		BCRP , ABC
T2590	Vismodegib	Erivedge,GDC-0449,RG 3616	Hedgehog/Smoothened , ABC , Autophagy
	Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).		Hedgehog/Smoothened , ABC , Autophagy
T9587	CCTA-1523		Others , ABC
	CCTA-1523 is an efflux function of ABCG2 inhibitor. CCTA-1523 selectively reverses ABCG2-mediated MDR in cancer cells.		Others , ABC
T20003	Acridone		Antibacterial , ABC
	Acridone could induce cell apoptosis, inhibited ABCG2 (ATP-binding cassette sub-family G member 2) protein, and adjusted hormone level.		Antibacterial , ABC
T3S1775	Tectochrysin	NSC 80687,Techtochrysine,Techtochrysin	NF-κB , STAT
	1. Tectochrysin (Techtochrysine) has antioxidant effect. 2. Tectochrysin is promising inhibitors for the reversal of ABCG2-mediated drug transport. 3. Tectochrysin leads to apoptotic cell death in NSC-LC cells through ac...		NF-κB , STAT
T2024	A-803467	A 803467,A803467	Sodium Channel
	A-803467 is a selective NaV1.8 channel blocker.		Sodium Channel
T16164	MY-5445	N-(3-chlorophenyl)-4-phenylphthalazin-1-amine	PDE
	MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM).		PDE
T5109	Avapritinib	BLU-285	PDGFR , c-Kit
	Avapritinib (BLU-285) is a dual inhibitor of the mutant KIT receptor (KIT D816V, IC50: 0.27 nM) and PDGFRα (PDGFRα D842V, IC50: 0.24 nM).		PDGFR , c-Kit
T0055L	Glafenine Hydrochloride	Glafenin hydrochloride	ABC
	Glafenine Hydrochloride is an anti-inflammatory agent.		ABC