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Glafenine Hydrochloride

Catalog No. T0055L CAS 65513-72-6

Synonyms: Glafenin hydrochloride

Glafenine Hydrochloride is an anti-inflammatory agent.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Glafenine Hydrochloride Chemical Structure

Glafenine Hydrochloride, CAS 65513-72-6

Pack Size	Availability	Price/USD
50 mg	In stock	$ 33.00
100 mg	In stock	$ 48.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 98.91%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Glafenine Hydrochloride is an anti-inflammatory agent.
Targets&IC50	ABCG2:3.2 μM
In vitro	Glafenine enhances the surface expression of mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in baby hamster kidney (BHK) cells, achieving 40% of the expression levels seen in wild-type CFTR[2]. Additionally, Glafenine hydrochloride suppresses the proliferation and clonogenic capabilities of human aortic smooth muscle cells (haSMCs) and endothelial cells (ECs) in a dose-responsive manner, leading to a blockade at the G2/M phase of the cell cycle and a decline in the G1 phase. Moreover, it dose-dependently impairs the migratory capacity of haSMCs and decreases the level of the extracellular matrix protein tenascin[3].
Cell Research	Glafenine hydrochloride is added to the culture medium of the smooth muscle cells at three concentrations (10 μM, 50 μM, 100 μM). After 4 days of treatment, cells are harvested and the absolute cell number is counted[3].

Synonyms	Glafenin hydrochloride
Molecular Weight	409.26
Formula	C19H17ClN2O4·HCl
CAS No.	65513-72-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL

References and Literature

1. Zhang Y, et al. Identification of inhibitors of ABCG2 by a bioluminescence imaging-based high-throughput assay. Cancer Res. 2009 Jul 15;69(14):5867-75. 2. Robert R, et al. Correction of the Delta phe508 cystic fibrosis transmembrane conductance regulator trafficking defect by the bioavailable compound glafenine. Mol Pharmacol. 2010 Jun;77(6):922-30. 3. Goldsmith, J., Cocchiaro, J., Rawls, J., & Jobin, C. (2012). Glafenine-induced intestinal injury in zebrafish is ameliorated by -opioid signaling via enhancement of Atf6-dependent cellular stress responses. Disease Models & Mechanisms, 6(1), 146-159. doi: 10.1242/dmm.009852

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Nonsteroidal Anti-Inflammatory Compound Library Approved Drug Library Anti-COVID-19 Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Glafenine Hydrochloride 65513-72-6 Membrane transporter/Ion channel ABC inhibit Glafenine Glafenin Inhibitor Glafenin Hydrochloride Glafenin hydrochloride inhibitor

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