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α-Lipoic Acid

Name: α-Lipoic Acid
Brand: TargetMol
SKU: T0200
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0200Cas No. 1077-28-7

Alias Thioctic acid, DL-α-Lipoic acid, 62-46-4, (±)-α-Lipoic acid, (±)-Lipoic acid

α-Lipoic Acid (DL-α-Lipoic acid) an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

α-Lipoic Acid

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Purity: 99.83%

Catalog No. T0200Alias Thioctic acid, DL-α-Lipoic acid, 62-46-4, (±)-α-Lipoic acid, (±)-Lipoic acidCas No. 1077-28-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.83%

Appearance:Solid

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

α-Lipoic Acid AI Summary

α-Lipoic Acid has exhibited a broad spectrum of bioactivity in various assays. It demonstrates significant inhibitory effects on Mycobacterial Glucosamine-1-phosphate acetyl transferase (GlmU) with an IC50 of 3910.0 nM and shows potency against the Menin-MLL interaction in MLL-Related Leukemias, as well as several other targets including Lamin A splicing, Thyroid Hormone Receptor interactions, and the retinoid-related orphan receptor gamma signaling pathway. Additionally, it induces the Endoplasmic Reticulum Stress Response in Human Glioma cells. The compound also displays anticancer properties, showing antiproliferative activity against a range of human cancer cell lines (such as K562, Bel7402, SGC7901, and A549) and exhibits cytotoxicity against human liver cells (L02) and peripheral blood mononuclear cells (PBMC), albeit with limited potency reflected by IC50 values greater than 50,000.0 nM. α-Lipoic Acid has demonstrated antiviral activity against SARS-CoV-2, with moderate to weak inhibitory effects on virus-induced cytotoxicity in VERO-6 cells at a concentration of 10 uM (IC50 > 19952.62 nM). It also shows a 24.81% and 14.23% inhibition rate of SARS-CoV-2 3CL-Pro protease at 20 µM in FRET-type assays. Moreover, α-Lipoic Acid inhibits human HDAC6 with approximately 7.98% and 7.9% inhibition in enzymatic assays. It significantly inhibits wild-type Candida albicans Fructose-1,6-Bisphosphate Aldolase transfected in Escherichia coli BL21 (DE3) by 80.0% at 50 uM concentration, as determined by spectrophotometric analysis. This compound also shows neuroprotective effects against amyloid beta (1 to 42)-induced neurotoxicity in human SH-SY5Y cells, enhancing cell viability and reducing necrosis rates in an Alzheimer's disease model. In terms of degradation and desulfhydration, α-Lipoic Acid releases hydrogen sulfide (H2S) in phosphate buffer with a half-life of 1.968 hours at 40 uM in the presence of L-cysteine, reaching a maximum concentration of 28400.0 nM of H2S. While α-Lipoic Acid binds to various receptors and enzymes, its activity is generally low, with no significant inhibitory or agonistic effects, as reflected by AC50 values above 30,000.0 nM in the provided data..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	α-Lipoic Acid (DL-α-Lipoic acid) an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Synonyms	Thioctic acid, DL-α-Lipoic acid, 62-46-4, (±)-α-Lipoic acid, (±)-Lipoic acid

Chemical Properties

Molecular Weight	206.33
Formula	C₈H₁₄O₂S₂
Cas No.	1077-28-7
Smiles	OC(=O)CCCCC1CCSS1
Relative Density.	1.218g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1211.65 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8466 mL	24.2330 mL	48.4660 mL	242.3302 mL
5 mM	0.9693 mL	4.8466 mL	9.6932 mL	48.4660 mL
10 mM	0.4847 mL	2.4233 mL	4.8466 mL	24.2330 mL
20 mM	0.2423 mL	1.2117 mL	2.4233 mL	12.1165 mL
50 mM	0.0969 mL	0.4847 mL	0.9693 mL	4.8466 mL
100 mM	0.0485 mL	0.2423 mL	0.4847 mL	2.4233 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

α-Lipoic Acid

α-Lipoic Acid

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