Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular Apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death.
Description | Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. |
In vitro | Ecdysone (10, 100 nM) induced the expression of a-smooth muscle actin (SMA). Ecdysone elevated the expression of cleaved caspase 3 in a dose dependent manner. Ecdysone (10, 100 nM) suppressed cell motility and scratch wound closure to a comparable extent[4]. Ecdysone (100 nM) induced a branched spindle mesenchymal-like cell shape. Ecdysone (100 nM) caused renal tubular inner medullary collecting duct cells apoptosis[4]. |
In vivo | In male C57BL/6 mice, Ecdysone (6 μg/g/day; s.c.) significantly impaired renal function, and BUN levels were statistically significantly increased, amplifying the renal expression of α-SMA. Ecdysone also displayed MR-dependent nephrotic effects[4]. |
Molecular Weight | 464.63 |
Formula | C27H44O6 |
CAS No. | 3604-87-3 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 60 mg/ml (129.14 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Ecdysone 3604-87-3 Apoptosis Autophagy Endocrinology/Hormones Membrane transporter/Ion channel Metabolism ATPase Glucocorticoid Receptor Potassium Channel Sodium Channel Endogenous Metabolite steroid Inhibitor hormone inhibit Crustecdysone metabolite transitions sleep homeostatic 20-hydroxyecdysone coordinating receptor regulation mineralocorticoid α-Ecdysone 20E developmental inhibitor