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Ecdysone
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Catalog No. TN3910Cas No. 3604-87-3
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death.
Ecdysone
😃Good
Catalog No. TN3910Cas No. 3604-87-3
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $133 | 35 days | |
| 5 mg | $443 | 35 days | |
| 10 mg | $750 | 35 days | |
| 25 mg | $1,560 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. |
| In vitro | Ecdysone (10, 100 nM) induced the expression of a-smooth muscle actin (SMA). Ecdysone elevated the expression of cleaved caspase 3 in a dose dependent manner. Ecdysone (10, 100 nM) suppressed cell motility and scratch wound closure to a comparable extent[4]. Ecdysone (100 nM) induced a branched spindle mesenchymal-like cell shape. Ecdysone (100 nM) caused renal tubular inner medullary collecting duct cells apoptosis[4]. |
| In vivo | In male C57BL/6 mice, Ecdysone (6 μg/g/day; s.c.) significantly impaired renal function, and BUN levels were statistically significantly increased, amplifying the renal expression of α-SMA. Ecdysone also displayed MR-dependent nephrotic effects[4]. |
| Molecular Weight | 464.63 |
| Formula | C27H44O6 |
| Cas No. | 3604-87-3 |
| Relative Density. | 1.22g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (129.14 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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Keywords
α-EcdysonetransitionssteroidSodiumChannelSodium ChannelsleepregulationreceptorPotassiumChannelPotassium ChannelMineralocorticoid ReceptormineralocorticoidmetaboliteInhibitorinhibitHuman Endogenous MetabolitehormonehomeostaticGlucocorticoidReceptorGlucocorticoid ReceptorEndogenousMetaboliteEndogenous MetaboliteEcdysonedevelopmentalCrustecdysonecoordinatingAutophagyATPaseApoptosis20-hydroxyecdysone20E
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