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Ecdysone

Catalog No. TN3910 CAS 3604-87-3

Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular Apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death.

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Ecdysone, CAS 3604-87-3

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Purity: 98%

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Description	Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death.
In vitro	Ecdysone (10, 100 nM) induced the expression of a-smooth muscle actin (SMA). Ecdysone elevated the expression of cleaved caspase 3 in a dose dependent manner. Ecdysone (10, 100 nM) suppressed cell motility and scratch wound closure to a comparable extent[4]. Ecdysone (100 nM) induced a branched spindle mesenchymal-like cell shape. Ecdysone (100 nM) caused renal tubular inner medullary collecting duct cells apoptosis[4].
In vivo	In male C57BL/6 mice, Ecdysone (6 μg/g/day; s.c.) significantly impaired renal function, and BUN levels were statistically significantly increased, amplifying the renal expression of α-SMA. Ecdysone also displayed MR-dependent nephrotic effects[4].

Molecular Weight	464.63
Formula	C27H44O6
CAS No.	3604-87-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 60 mg/ml (129.14 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Gautam NK, Verma P, Tapadia MG. Ecdysone regulates morphogenesis and function of Malpighian tubules in Drosophila melanogaster through EcR-B2 isoform. Dev Biol. 2015 Feb 15;398(2):163-76. 2. Nishita Y. Ecdysone response elements in the distal promoter of the Bombyx Broad-Complex gene, BmBR-C. Insect Mol Biol. 2014 Jun;23(3):341-56. 3. Minglei Lu, et al. Activation of Mineralocorticoid Receptor by Ecdysone, an Adaptogenic and Anabolic Ecdysteroid, Promotes Glomerular Injury and Proteinuria Involving Overactive GSK3β Pathway Signaling. Sci Rep. 2018 Aug 15;8(1):12225. 4. Minglei Lu, et al. Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities. Cell Physiol Biochem. 2018;49(4):1633-1645.

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Keywords

Ecdysone 3604-87-3 Apoptosis Autophagy Endocrinology/Hormones Membrane transporter/Ion channel Metabolism ATPase Glucocorticoid Receptor Potassium Channel Sodium Channel Endogenous Metabolite steroid Inhibitor hormone inhibit Crustecdysone metabolite transitions sleep homeostatic 20-hydroxyecdysone coordinating receptor regulation mineralocorticoid α-Ecdysone 20E developmental inhibitor

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