upa — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T29051	UK-122 TFA salt	UK122,uPA Inhibitor II,UK122 TFA salt,UK 122,UK-122,K122 trifloroacetic acid
	UK-122 is a potent and selective uPA inhibitor (Ki = 20 nM). The IC(50) of UK122 in a cell-free indirect uPA assay is 0.2 micromol/L. UK122 showed little cytotoxicity against CFPAC-1 cells (IC(50) > 100 micromol/L) but s...
T13408	ZK824190		Others , Serine Protease
	ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA) as a potential treatment for multiple sclerosis(IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively).		Others , Serine Protease
T8362	Benzamidine hydrochloride	Benzamidine HCl	Serine/threonin kinase , Serine Protease
	Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 μM, respectively).		Serine/threonin kinase , Serine Protease
T13257	Upamostat		PAI-1 , Serine/threonin kinase , Serine Protease
	Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.		PAI-1 , Serine/threonin kinase , Serine Protease
T77566	(3aR,9aR)-Fluparoxan		Adrenergic Receptor
	(3aR,9aR)-Fluparoxan is a highly selective and potent adrenergic receptor α2B antagonist for the prevention, amelioration or treatment of neurodevelopmental disorders and neurodegenerative diseases.		Adrenergic Receptor
T61932	Nesuparib	JPI-547/OCN-201	PARP , Wnt/beta-catenin
	Nesuparib (JPI-547/OCN-201) is a potent PARP inhibitor with inhibitory effects on PARP and TNKS1.Nesuparib has antitumor activity and can be used in the treatment of tumors, endocrine and metabolic disorders, genitourina...		PARP , Wnt/beta-catenin
T7503	Upadacitinib	ABT-494	JAK
	Upadacitinib (ABT-494) (ABT-494) is a selective Janus kinase (JAK) 1 inhibitor, which is being studied for the treatment of several autoimmune disorders in the IC50 of 43 nM.		JAK
T1827	Buparlisib	BKM120,NVP-BKM120	Apoptosis , PI3K
	Buparlisib (BKM120) is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110α, p110β, and p110δ).		Apoptosis , PI3K
T3362	Eupatilin	NSC 122413	PPAR , Autophagy
	Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.		PPAR , Autophagy
T76735	Mupadolimab	CPI-006	CD73
	Mupadolimab (CPI-006) is a humanized FC-γR binding deficient IgG1 anti-CD73 antibody with potential anticancer activity and activation of CD73POS B cells.		CD73
T11122	DUPA(OtBu)-OH		Others
	DUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer. PSMA has a high affinity ...		Others
T19301	DUPA	N,N''-Carbonylbis[L-glutamic acid],(2S,2'S)-2,2'-Carbonylbis(Azanediyl)Dipentanedioic Acid	Others , Ligands for Target Protein for PROTAC
	DUPA (N,N''-Carbonylbis[L-glutamic acid]) is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.		Others , Ligands for Target Protein for PROTAC
T77565	Fluparoxan hydrochloride		Adrenergic Receptor
	Fluparoxan hydrochloride is a highly selective and potent α2-adrenoceptor antagonist for the prevention, amelioration or treatment of neurodevelopmental disorders and neurodegenerative diseases.		Adrenergic Receptor
TN3469	Aucuparin	2,6-dimethoxy-4-phenylphenol	NADPH-oxidase
	Aucuparin (2,6-dimethoxy-4-phenylphenol) is a plant antibiotic with anti-inflammatory activity. Aucuparin inhibited pulmonary fibrosis in mouse models induced by bleomycin (BLM). ABTS and FRAP showed clear scavenging act...		NADPH-oxidase
T6242	Rupatadine Fumarate	Rinialer,Rupafin,Alergoliber	PAFR , Autophagy , Histamine Receptor
	Rupatadine Fumarate (Rinialer) (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.		PAFR , Autophagy , Histamine Receptor
T5826	Eupalinolide A		HSP
	Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.		HSP
T29067L	Upacicalcet HCl	Upacicalcet HCl(1333218-50-0 Free base)	CaSR
	Upacicalcet HCl is an intravesical calcium mimetic that inhibits excessive parathyroid hormone (PTH) secretion by directly acting on calcium-sensitive receptors in parathyroid cell membranes, thereby lowering PTH levels ...		CaSR
T29067	Upacicalcet	PLS-240,SK-1403,AJT-240	Calcium Channel
	Upacicalcet (AJT-240) is an intraventricular calcium mimetic, a SHPT available for human hemodialysis, that inhibits excessive parathyroid hormone (PTH) secretion by directly acting on parathyroid cell membrane calcium-s...		Calcium Channel
T4269	Buparvaquone	Butalex,BW 720C	Antibiotic , Parasite
	Buparvaquone (BW 720C) is a hydroxynaphthoquinone antiprotozoal drug related to atovaquone and parvaquone.		Antibiotic , Parasite
T77412	Lupartumab	BAY 1112623	Others
	Lupartumab (BAY 1112623) is an anti-LYPD3 (C4.4A) monoclonal antibody that can be used to synthesize antibody-active molecular couplers that can be used to study LYPD3-associated tumor diseases.		Others