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Upamostat

Catalog No. T13257 CAS 590368-25-5

Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.

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Upamostat, CAS 590368-25-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 97.00
5 mg	In stock	$ 247.00
10 mg	In stock	$ 397.00
25 mg	In stock	$ 663.00
50 mg	In stock	$ 945.00
100 mg	In stock	$ 1,280.00
1 mL * 10 mM (in DMSO)	In stock	$ 343.00

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Purity: 98.80%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.

In vitro

Upamostat is an inhibitor of urokinase plasminogen activator (uPA). Upamostat is the oral prodrug of the active metabolite WX-UK1, a novel inhibitor of uPA [1]. Upamostat inhibits the urokinase-type plasminogen activator (uPA) system, and plays a major role in tumor invasion and metastasis. Upamostat is the orally available amidoxime- (i.e. hydroxyamidine-) prodrug of the pharmacologically active form, WX-UK1 [2].

Molecular Weight	629.81
Formula	C32H47N5O6S
CAS No.	590368-25-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (396.95 mM)

References and Literature

1. Heinemann V, et al. Phase II randomised proof-of-concept study of the urokinase inhibitor upamostat (WX-671) in combination with gemcitabine compared with gemcitabine alone in patients with non-resectable, locally advanced pancreatic cancer. Br J Cancer. 2013 Mar 5;108(4):766-70. 2. Froriep D, et al. Activation of the anti-cancer agent upamostat by the mARC enzyme system. Xenobiotica. 2013 Sep;43(9):780-4. 3. Park C, et al. HPLC-MS/MS analysis of mesupron and its application to a pharmacokinetic study in rats. J Pharm Biomed Anal. 2018 Feb 20;150:39-42.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Cell Cycle Compound Library Metabolism Compound Library ReFRAME Related Library Bioactive Compounds Library Max Kinase Inhibitor Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Upamostat 590368-25-5 Cell Cycle/Checkpoint Metabolism Proteases/Proteasome PAI-1 Serine/threonin kinase Serine Protease inhibit Threonine proteases WX 671 Inhibitor Ser/Thr Protease Plasminogen activator inhibitor-1 Serine endopeptidases WX-671 WX671 Serine proteases inhibitor

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