sensitivity — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T14984	CLP257		Potassium Channel
	CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it al...		Potassium Channel
T2626	SBC-115076	SBC115076	Others , Serine/threonin kinase
	SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.		Others , Serine/threonin kinase
T8526	Metformin	1,1-Dimethylbiguanide	Mitophagy , AMPK , Autophagy
	Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is comm...		Mitophagy , AMPK , Autophagy
T0740	Metformin hydrochloride	Metformin HCl,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride	Mitophagy , AMPK , Autophagy
	Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) , a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells including colon, pro...		Mitophagy , AMPK , Autophagy
T7486	Imeglimin hydrochloride	EMD 387008 hydrochloride	Reactive Oxygen Species , Mitochondrial Metabolism
	Imeglimin hydrochloride (EMD 387008 hydrochloride) prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.		Reactive Oxygen Species , Mitochondrial Metabolism
TN1275	P-Hydroxyphenethyl anisate	4-Hydroxyphenethylanisate	Others
	p-Hydroxyphenethyl anisate (4-Hydroxyphenethylanisate), a natural product from Notopterygium forbe-siiBoiss, is a novel polymeric sustained-release material that, after block copolymerization with AAPBA, produces nanopar...		Others
T13918	Tecalcet Hydrochloride	R-568 hydrochloride,R-568 (hydrochloride)	CaSR
	Tecalcet Hydrochloride (R-568 hydrochloride) is an allosteric and positive modulator of the calcium-sensing receptor(CaSR). Tecalcet Hydrochloride increases the sensitivity to the activation of extracellular Ca2+.		CaSR
T20600	Kaolin	Clay 347,Hydrated aluminum silicate,Bolus alba,HSDB 630,Altowhite,China clay	Others
	Kaolin (Bolus alba) is a clay dominated by minerals of the kaolinite family. Kaolin increased the sensitivity of this method for monitoring hemophilia therapy.		Others
T40684	N-Nitrosomorpholine		Others
	N-Nitrosomorpholine, a nitrosamine compound, exhibits sensitivity to light and is recognized as a potent carcinogen in animals.		Others
T4018	WST-8	WST8	Others
	WST-8 is a water-soluble tetrazolium dye, the sensitivity of the WST-8(WST8)-based assay is higher than the conventional MTS-based assay.		Others
TN5137	Tetramethylkaempferol		transporter , PPAR
	Tetramethylkaempferol is a PPARγ agonist, it can improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Tetramethylkaempfero...		transporter , PPAR
T5S0669	Bergamottin	5-Geranoxypsoralen,Bergamotine,Bergaptin	P450
	1. Bergamottin (5-Geranoxypsoralen) can significantly reduce blood glucose and increase glucose tolerance and insulin sensitivity in KK-A^ydiabetic mice.		P450
T67912	PA3552-IN-1
	PA3552-IN-1 is an antibiotic adjuvant that can reduce the expression of PA3552 and restore the sensitivity of MDR Pseudomonas aeruginosa DK2 strain to Polymyxin B.
T2530	Levosimendan	OR1259,OR1855	Potassium Channel , PDE , Carbonic Anhydrase , Autophagy
	Levosimendan (OR1259) is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calcium, thus increasing cardiac contractility without ...		Potassium Channel , PDE , Carbonic Anhydrase , Autophagy
T5S0229	Isosakuranetin	4'-Methylnaringenin	Others
	1. Isosakuranetin (4'-Methylnaringenin) has cytotoxic and fungicide properties. 2. Isosakuranetin produces significant decrease in blood pressure. 3. Isosakuranetin significantly reduces the sensitivity of mice to noxiou...		Others
T2406	Cinacalcet hydrochloride	AMG-073 HCl,Cinacalcet HCl,AMG-073 hydrochloride,Cinacalcet	CaSR
	Cinacalcet hydrochloride (AMG-073 hydrochloride) is a naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-sensing receptors to serum calcium. This action reduces para...		CaSR
T4785	Oxfenicine	4-Hydroxy-L-phenylglycine	Others
	Oxfenicine (4-Hydroxy-L-phenylglycine) is a carnitine palmitoyltransferase-1 inhibitor. Oxfenicine improves whole-body glucose tolerance and insulin sensitivity in high-fat diet-induced obese mouse with insulin resistanc...		Others
T8929	BC1618	2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-	Mitophagy , Others , E1/E2/E3 Enzyme , AMPK
	BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling. It promotes mitochondrial fission, promotes autophagy and imp...		Mitophagy , Others , E1/E2/E3 Enzyme , AMPK
T40711	H-D-Phe-Pip-Arg-pNA dihydrochloride	S-2238 dihydrochloride,H-D-Phe-Pip-Arg-pNA dihydrochloride	Others
	H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride), a chromogenic substrate, mimics the N-terminal fragment of the A alpha chain of fibrinogen, the native substrate of thrombin. Specifically designed for thromb...		Others
T3999	D(+)-Galactosamine hydrochloride	D-Galactosamine HCl	Others
	D(+)-Galactosamine hydrochloride (D-Galactosamine HCl) hepatotoxicity is associated with endotoxin sensitivity and mediated by lymphoreticular cells in mice.		Others