Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tecalcet Hydrochloride (R-568 hydrochloride) is an allosteric and positive modulator of the calcium-sensing receptor(CaSR). Tecalcet Hydrochloride increases the sensitivity to the activation of extracellular Ca2+.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
2 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 70.00 | |
10 mg | In stock | $ 116.00 | |
25 mg | In stock | $ 263.00 | |
50 mg | In stock | $ 428.00 | |
100 mg | In stock | $ 623.00 | |
200 mg | In stock | $ 882.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 77.00 |
Description | Tecalcet Hydrochloride (R-568 hydrochloride) is an allosteric and positive modulator of the calcium-sensing receptor(CaSR). Tecalcet Hydrochloride increases the sensitivity to the activation of extracellular Ca2+. |
In vitro | Tecalcet Hydrochloride (0.1-100 nM) shifts the concentration-response curve for extracellular Ca2 to the left and decreases the EC50 value to 0.61 mM. Tecalcet Hydrochloride (0.1-100 μM) increases Ca2+ in a dose-dependent and stereoselective manner[3]. |
In vivo | In male Sprague-Dawley rats with renal insufficiency, Tecalcet Hydrochloride (1.5 and 15 mg/kg, oral) inhibits PT cell proliferation and reduces serum PTH level in a dose-dependent manner. Tecalcet Hydrochloride reduces the number of BrdU-positive PT cells by 20% at a low dose (1.5 mg/kg), and by 50% at a high dose (15 mg/kg)[1]. |
Synonyms | R-568 hydrochloride, R-568 (hydrochloride) |
Molecular Weight | 340.29 |
Formula | C18H23Cl2NO |
CAS No. | 177172-49-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (117.5 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Tecalcet Hydrochloride 177172-49-5 GPCR/G Protein CaSR R568 R-568 R-568 hydrochloride R568 Hydrochloride R-568 (hydrochloride) R 568 R-568 Hydrochloride R 568 Hydrochloride inhibitor inhibit