store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is commonly used in type 2 diabetes research.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 39.00 | |
25 mg | In stock | $ 64.00 | |
50 mg | In stock | $ 89.00 | |
100 mg | In stock | $ 109.00 | |
500 mg | In stock | $ 277.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 39.00 |
Description | Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is commonly used in type 2 diabetes research. |
In vitro |
METHODS: Ovarian cancer cells A2780 and SKOV3 were treated with Metformin (0.001-50 mM) for 24-48 h. Cell viability was assayed using the MTS RESULTS: Micromolar concentrations of Metformin did not statistically reduce the viability of the A2780 or SKOV3 cell lines. At 48 h, millimolar concentrations resulted in cell death. [1] METHODS: Human colorectal cancer cells HCT29 were treated with Metformin (0.6 mM) for 90 h. Cell motility was detected using the wound healing assay and chamber invasion assay. RESULTS: Metformin inhibited the migration and invasion of HCT29 cells, and Metformin decreased the motility of tumor cells. [2] |
In vivo |
METHODS: To model Metformin-induced diarrhea, Metformin (125-500 mg/kg) was administered orally to healthy and diabetic obese db/db C57BL/6J mice twice daily for thirteen days. RESULTS: Metformin at 1000 mg/kg/day significantly increased fecal water content. Although no diarrhea symptoms were observed in healthy C57BL/6J mice, the same dose of Metformin induced severe diarrhea in diabetic obese db/db mice. [3] METHODS: To investigate the protective effect of Metformin in radiation injury, Metformin (200 mg/kg once daily for three days) was administered orally to BALB/c mice, which were then exposed to 6-8 Gy of gamma radiation. RESULTS: When administered prior to exposure to radiation, Metformin prolonged the survival of mice exposed to 8 Gy-TBI and increased the survival of mice exposed to 6 Gy-TBI. Pretreatment with Metformin attenuated radiation damage. [4] |
Synonyms | 1,1-Dimethylbiguanide |
Molecular Weight | 129.16 |
Formula | C4H11N5 |
CAS No. | 657-24-9 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 26 mg/mL (201.3 mM)
H2O: 26 mg/mL (201.3 mM)
You can also refer to dose conversion for different animals. More
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Metformin 657-24-9 Autophagy Chromatin/Epigenetic PI3K/Akt/mTOR signaling Mitophagy AMPK inhibit barrier mitochondrial chain liver Inhibitor diabetes blood-brain respiratory type sensitivity AMP-activated protein kinase Mitochondrial Autophagy 1,1-Dimethylbiguanide insulin inhibitor