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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN6730 | Epoxyazadiradione | NF-κB | |
Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cells. | |||
TQ0218 | Deoxyandrographolide | 14-deoxyandrographolide | IL Receptor , TNF |
Deoxyandrographolide (14-deoxyandrographolide) potentiates NGF-induced neurite outgrowth. Deoxyandrographolide suppresses the production of proinflammatory mediators TNF-α and IL-6. | |||
T28628 | RVX-297 | RVX297 | Epigenetic Reader Domain |
RVX-297 is a BD2 selective inhibitor of BET bromodomains. RVX-297 preferentially binds to the BD2 domains of the BET bromodomain and Extra Terminal (BET) family of protein. | |||
T6716 | Valsartan | Diovan,Tareg,CGP 48933 | RAAS |
Valsartan (CGP 48933) is a tetrazole derivative and angiotensin II type 1 receptor blocker that is used to treat hypertension. | |||
T7926 | Carmoisine | Azo Rubine,Chromotrope FB | Others |
Carmoisine (Azo Rubine) is a food dye Azorubine and is used for the purposes where food is heat-treated after fermentation. | |||
T2036 | 6-OAU | GTPL5846 | GPR |
6-OAU (GTPL5846)(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay. | |||
T4602 | Hydrocortisone hemisuccinate | Hydrocortisone 21-he,hydrocortisone 21-hemisuccinate*free acid,Hydrocortisone 21-hemisuccinate | Glucocorticoid Receptor , Others , Interleukin |
Hydrocortisone hemisuccinate (hydrocortisone 21-hemisuccinate*free acid) is a corticosteroid used as an analytical and chromatography reagent. | |||
TQ0054 | Purpureaside C | Others | |
Purpureaside C is a phenolic glycoside with significant proinflammatory, immunomodulating and antimicrobial effects. | |||
T7317 | CU-CPT-9a | TLR | |
CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells- | |||
T11765 | KPLH1130 | Dehydrogenase , PDK | |
KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macrophage polarization and mitigates proinflammatory reactions. | |||
T10689 | Cauloside D | Others | |
Cauloside D, a triterpene glycoside isolated from Caulophyllum robustum Max, inhibits the expression of iNOS and proinflammatory cytokines with anti-inflammatory effects. | |||
T11492 | GSK2983559 free acid | Others , RIP kinase | |
GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking many proinflammatory cytokine responses in human inflammato... | |||
T5660 | Menthone | IL Receptor , TNF , NF-κB , Parasite | |
Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha),as well as nuclear factor k... | |||
T3887 | Rosarin | Others | |
Rosarin has anti-inflammatory and neuroprotective effects. Rosarin supresses the expression of the proinflammatory factors iNOS, IL-1 β, and TNF- α in the kidney and prefrontal cortex of brain in mice . | |||
T11598 | IAXO-102 | TLR | |
IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdomin... | |||
T1127 | Beclometasone dipropionate | Beclovent,Beclomethasone dipropionate,Beconase,Vancenase | Glucocorticoid Receptor |
Beclometasone dipropionate (Vancenase) is the dipropionate ester of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, beclomethasone... | |||
T2401 | Alogliptin Benzoate | SYR 322,Alogliptin(SYR-322)benzoate | Ferroptosis , Proteasome , DPP-4 |
Alogliptin Benzoate (SYR 322)(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alogliptin may inhibit inflammatory responses by preventing the... | |||
TJS0315 | 4-Methyldaphnetin | 7,8-Dihydroxy-4-methylcoumarin,DHMC | Apoptosis , Lipoxygenase |
4-Methyldaphnetin (DHMC) is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydr... | |||
T2S2173 | (E)-Naringenin chalcone | Isosalipurpol,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone | Others |
Naringenin chalcone (Isosalipurpol) has antiallergic activity Naringenin chalcone suppresses asthmatic symptoms by inhibiting Th2 cytokine production from CD4 T cells. Naringenin chalcone is a potent tomato flavonoid tha... | |||
T15017 | CU-T12-9 | TLR | |
CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activat... |