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KPLH1130

Catalog No. T11765 CAS 906669-07-6

KPLH1130 improves glucose tolerance in HFD-fed mice. KPLH1130 is a specific pyruvate <a href="/target/Dehydrogenase" style="display: inline; color: #c13a36">Dehydrogenase</a> kinase (<a href="/target/PDK" style="display: inline; color: #c13a36">PDK</a>) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses.

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KPLH1130, CAS 906669-07-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 81.00
5 mg	In stock	$ 231.00
10 mg	In stock	$ 369.00
25 mg	In stock	$ 693.00
50 mg	In stock	$ 1,057.00
100 mg	In stock	$ 1,462.00
200 mg	In stock	$ 2,193.00

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Purity: 98.43%

Biological Description

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Description

KPLH1130 improves glucose tolerance in HFD-fed mice. KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses.

Molecular Weight	283.28
Formula	C15H13N3O3
CAS No.	906669-07-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 130 mg/mL (458.91 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Min BK, et al. Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype. Front Immunol. 2019 May 7;10:944.

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Anti-Obesity Compound Library PI3K-AKT-mTOR Compound Library Reprogramming Compound Library Antioxidant Compound Library Kinase Inhibitor Library Anti-Colorectal Cancer Compound Library Anti-Liver Cancer Compound Library Anti-Lung Cancer Compound Library Anti-Pancreatic Cancer Compound Library

Related Products

Related compounds with same targets

6''-O-Acetylglycitin DSM421 ADH-1 BRD9185 AZD8329 CGRP antagonist 1 TC HSD 21 T-3764518

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KPLH1130 906669-07-6 Metabolism PI3K/Akt/mTOR signaling Dehydrogenase PDK KPLH 1130 Pyruvate dehydrogenase kinase PDH kinase KPLH-1130 inhibit Inhibitor PDHK inhibitor

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