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CU-T12-9

Catalog No. T15017 CAS 1821387-73-8

CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS.

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CU-T12-9, CAS 1821387-73-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 108.00
2 mg	In stock	$ 153.00
5 mg	In stock	$ 228.00
10 mg	In stock	$ 297.00
25 mg	In stock	$ 375.00
50 mg	In stock	$ 455.00
100 mg	In stock	$ 657.00
500 mg	In stock	$ 1,360.00
1 mL * 10 mM (in DMSO)	In stock	$ 198.00

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Purity: 99.93%

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Storage & Solubility Information

Description	CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS.
Targets&IC50	TLR2:52.9 nM （EC50）（in HEK-Blue cells), TLR1:52.9 nM （EC50）（in HEK-Blue cells)
In vitro	CU-T12-9 directly targets TLR1/2 to initiate downstream signaling.?CU-T12-9 specifically induces TLR1/2 activation, which can be blocked by either the anti-hTLR1 or the anti-hTLR2 antibody, but not the anti-hTLR6 antibody.?By binding to both TLR1 and TLR2, CU-T12-9 facilitates the TLR1/2 heterodimeric complex formation, which in turn activates the downstream signaling.?Fluorescence anisotropy assays revealed competitive binding to the TLR1/2 complex between CU-T12-9 and Pam3CSK4 with a half-maximal inhibitory concentration (IC50) of 54.4 nM.?CU-T12-9 signals through nuclear factor κB (NF-κB) and invokes an elevation of the downstream effectors tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), and inducible nitric oxide synthase (iNOS)[1].?

Molecular Weight	362.31
Formula	C17H13F3N4O2
CAS No.	1821387-73-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (690.02 mM), Sonication is recommended.

References and Literature

1. Cheng K, et al. Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists. Sci Adv. 2015;1(3). pii: e1400139.

Related compound libraries

This product is contained In the following compound libraries：

Immunology/Inflammation Compound Library NO PAINS Compound Library Bioactive Compound Library Immuno-Oncology Compound Library Bioactive Compounds Library Max Pyroptosis Compound Library Reprogramming Compound Library

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Keywords

CU-T12-9 1821387-73-8 Immunology/Inflammation TLR obesity inflammatory carcinoma cancer Toll-like Receptor (TLR) TLR1/2 diseases specific infectious bladder CU-T-12-9 CUT129 Inhibitor breast asthma CU T12 9 inhibit influenza pancreatic inhibitor

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