penetrate — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T15799	LY2940094	LY-2940094	Opioid Receptor
	LY2940094 (LY-2940094) decreases ethanol self-administration in animal models. LY2940094 is an effective, selective, and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist pot...		Opioid Receptor
T9288	Keratin hydrolyzed		Others
	Keratin hydrolyzed is a processed form of keratin that allows it to penetrate the hair cuticle.		Others
TP1185L	Cys-TAT(47-57) acetate(583836-55-9 Free base)	Cys-TAT(47-57) acetate（583836-55-9 Free base）	HIV Protease
	Cys-TAT(47-57) acetate is derived from the HIV-1 transactivating protein. Cys-TAT(47-57) acetate is an arginine rich peptide that can penetrate cells.		HIV Protease
T6107	IU1		DUB , Autophagy
	IU1(IC50=4.7 μ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell.		DUB , Autophagy
T12451	Phosphoenolpyruvic acid tricyclohexylammonium salt	PEP 3 CHA,phosphoenolpyruvic-acid-tricyclohexylammonium-salt,phosphoenolpyruvic-acid-tricyclohexylammoniu-m-salt	Others
	Phosphoenolpyruvic acid tricyclohexylammonium salt (PEP 3 CHA) is a functional carbohydrate metabolite with cytoprotective and anti-oxidative activity. Phosphoenolpyruvic acid tricyclohexylammonium salt is able to penetr...		Others
T60644	SJ000063181		TGF-beta/Smad
	SJ000063181 is a potent activator of BMP signaling, exhibiting an EC50 of ≤1 μM. It serves as a valuable chemical probe for BMP signaling analysis, owing to its ability to penetrate zebrafish embryos.		TGF-beta/Smad
T5397	A-381393		Dopamine Receptor
	A-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6 nM for human dopamine D4.2/D4.4/D4.7 receptor).		Dopamine Receptor
T5058	Pamiparib	BGB-290	PARP
	Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor(IC50 of 0.9 nM and 0.5 nM for PARP1 and PARP2, respectively). It has potent PARP trapping, and capability to penetrate the brain, and can b...		PARP
T2335	Ebastine	Ebastel,LAS-W 090,Ebastin,Kestine,RP64305	Histamine Receptor
	Ebastine (Kestine) (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an effective block of the H1 receptor in peripheral tiss...		Histamine Receptor
T10202	A 1070722		GSK-3
	A 1070722 is a potent and selective GSK-3 inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. It can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for...		GSK-3
T23046	N-tert-butyl-α-Phenylnitrone	(Z)-N-benzylidene-2-Methylpropan-2-aMine oxide	ROS , COX
	N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity. N-tert-butyl-α-Phenylnitrone((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) possesses potent reactive oxyge...		ROS , COX
T0402	Octocrylene	Octocrilene	Others
	Octocrylene (Octocrilene) is used as an ingredient in sunscreens and cosmetics. This organic compound can penetrate into the skin where it acts as a photosensitizer. This results in an increased production of free radica...		Others
T60707	Quinupramine
	Quinupramine is an orally active antidepressant that shows antidepressant activity associated with the central serotonin system, but not with the β-adrenergic system. Quinupramine is able to penetrate into the CNS and af...
T6726	VU0361737	ML-128,VU 0361737	GluR
	VU0361737 (ML-128) is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 is110 nM for rat receptors.It exhibits weak activity...		GluR
T26684	Auten-99 HBr	Auten-99,Auten-99 hydrochloride. Auten-99 HBr,Auten99,Auten 99	Phosphatase
	Auten-99 HBr (Auten-99) is a myotubularin phosphatase Jumpy inhibitor exerting potent neuroprotective effects. AUTEN-99 activates autophagy in cell cultures and animal models. AUTEN-99 appears to effectively penetrate th...		Phosphatase
T4S0800	Demethyleneberberine		P450 , NOS , NF-κB , HIF , AMPK
	Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1,...		P450 , NOS , NF-κB , HIF , AMPK
T5465	PF-5274857	PF-5274857 freebase	Smo
	PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor t...		Smo
T14938	CGP 36742	SGS-742	GABA Receptor
	CGP 36742 is a selective antagonist of the GABAB receptor that can penetrate the blood-brain barrier after peripheral administration (IC50: 32 μM). It is useful in the treatment of depression.		GABA Receptor
T37406	Apovincaminic acid hydrochloride salt
	Apovincaminic acid hydrochloride salt, the primary active metabolite of Vinpocetine (VP), is orally active and has the ability to penetrate the brain. It demonstrates a neuroprotective mechanism of action [1][2].
T68527	Temelastine
	Temelastine is a selective, competitive histamine H1-receptor antagonist which does not penetrate the central nervous system.