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Auten-99 HBr

Catalog No. T26684 CAS 1049780-58-6

Synonyms: Auten-99, Auten-99 hydrochloride. Auten-99 HBr, Auten99, Auten 99

Auten-99 HBr (Auten-99) is a myotubularin phosphatase Jumpy inhibitor exerting potent neuroprotective effects. AUTEN-99 activates autophagy in cell cultures and animal models. AUTEN-99 appears to effectively penetrate through the blood-brain barrier, and impedes the progression of neurodegenerative symptoms in Drosophila models of Parkinson’s and Huntington’s diseases. Furthermore, the molecule increases the survival of isolated neurons under normal and oxidative stress-induced conditions. Thus, AUTEN-99 serves as a potent neuroprotective drug candidate for preventing and treating diverse neurodegenerative pathologies, and may promote healthy aging.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Auten-99 HBr, CAS 1049780-58-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 119.00
5 mg	In stock	$ 243.00
10 mg	In stock	$ 392.00
25 mg	In stock	$ 656.00
50 mg	In stock	$ 933.00
100 mg	In stock	$ 1,270.00
500 mg	In stock	$ 2,530.00
1 mL * 10 mM (in DMSO)	In stock	$ 278.00

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Purity: 98.37%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Auten-99, Auten-99 hydrochloride. Auten-99 HBr, Auten99, Auten 99
Molecular Weight	359.28
Formula	C17H15BrN2S
CAS No.	1049780-58-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11 mg/ml (30.62 mM)

References and Literature

1. Erdos Attila, Vellai Tibor. Compounds For Enhancing Autophagy.WO/2018/130863 2. Kovács T, Billes V, Komlós M, Hotzi B, Manzéger A, Tarnóci A, Papp D, Szikszai F, Szinyákovics J, Rácz Á, Noszál B, Veszelka S, Walter FR, Deli MA, Hackler L Jr, Alfoldi R, Huzian O, Puskas LG, Liliom H, Tárnok K, Schlett K, Borsy A, Welker E, Kovács AL, Pádár Z, Erdős A, Legradi A, Bjelik A, Gulya K, Gulyás B, Vellai T. The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms. Sci Rep. 2017 Feb 16;7:42014. doi: 10.1038/srep42014. PubMed PMID: 28205624; PubMed Central PMCID: PMC5311965.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Phosphatase Inhibitor Library Bioactive Compounds Library Max Metabolism Compound Library Glycometabolism Compound Library NO PAINS Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Auten-99 HBr 1049780-58-6 Metabolism Phosphatase Auten-99 Autophagy enhancer99 Auten 99 HBr Auten-99 hydrochloride. Auten-99 HBr Autophagy enhancer-99 Auten99 Auten 99 inhibit Autophagy enhancer 99 Auten99 HBr Inhibitor inhibitor

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