neurotransmission — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN1023	Miltirone		P450 , GABA Receptor
	Miltirone is a CYPs inhibitor, it has been characterized as a low-affinity ligand for central benzodiazepine receptors.		P450 , GABA Receptor
T0322	Fipexide		Dopamine Receptor , AChR
	Fipexide (Attentil, Vigilor), a psychoactive drug of the piperazine chemical class, was developed in Italy in 1983. It was served as a nootropic drug in France and Italy, mainly for the therapy of senile dementia, but is...		Dopamine Receptor , AChR
T21995	XAP044		GluR
	XAP044 is a mGlu7-selective antagonist which inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice with a half-maximal blockade at 88 nm[1].		GluR
T9461	AZ194		Sodium Channel
	CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.		Sodium Channel
T6728	VUF 10166		5-HT Receptor
	VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.		5-HT Receptor
T11349	GABAA receptor agent 1		GABA Receptor
	GABAA receptor agent 1 has strong anticonvulsant activity and is a high affinity ligand of GABAA receptor.		GABA Receptor
T7823	IDRA-21		GluR
	IDRA-21 is a positive AMPA receptor modulator.		GluR
T8333	Aurintricarboxylic acid	ATA,NSC-4056,NSC4056,NSC 4056	Apoptosis , P2X Receptor , Influenza Virus , Topoisomerase
	Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.		Apoptosis , P2X Receptor , Influenza Virus , Topoisomerase
T9409	Mesdopetam hemitartrate	IRL790 hemitartrate,1-Propanamine, N-[2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl]-, (2R,3R)-2,3-dihydroxybutanedioate (2:1)	Dopamine Receptor
	Mesdopetam hemitartrate (IRL790 hemitartrate) is an antagonist of dopamine D3 receptor (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor). It has psychomotor stabilizing properties.		Dopamine Receptor
T16533	Picrotin		Chloride channel
	Picrotin is an inhibitor of glycine receptors. Picrotin blocks α2 GlyR, α1 GlyR, and α3 GlyR and can be used in studies about neurotransmission.		Chloride channel
T34399	Rovatirelin	KPS-0373,S0373,S-0373,S 0373	AChE
	Rovatirelin (S-0373) is a newly synthesized thyrotropin-releasing hormone (TRH) analog that ameliorates cytosine arabinoside-induced motor dysfunction in a rat model of spinal cerebellar degeneration via acetylcholine an...		AChE
T7549	Talnetant	SB 223412	Neurokinin receptor
	Talnetant (SB 223412) is a selective, competitive, brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic neurotransmission		Neurokinin receptor
T69552	Suzetrigine	VX-548	Sodium Channel
	Suzetrigine（VX-548） is an orally active and specific NaV1.8 inhibitor. Suzetrigine has analgesic activity and can be used to study acute pain and neurotransmission.		Sodium Channel
T20828	Citalopram	Cipram,Lu 10-171,Lu-10-171 Lu10-171	5-HT Receptor
	Citalopram (Lu 10-171 is an orally active, selective serotonin reuptake inhibitor (SSRI), a selective 5-hydroxytryptamine reuptake inhibitor, and a racemic mixture of the S(+)-enantiomer (Escitalopram) and the R(-)-enant...		5-HT Receptor
T60707	Quinupramine
	Quinupramine is an orally active antidepressant that shows antidepressant activity associated with the central serotonin system, but not with the β-adrenergic system. Quinupramine is able to penetrate into the CNS and af...
T20089	ATP	Atipi,ATP disodium salt hydrate,Triphosphoric acid adenosine ester,Ara-ATP,Triphosphaden,Adenosine triphosphate;Ara-ATP,Adenosine triphosphate	Endogenous Metabolite
	ATP (Adenosine triphosphate) provides cellular energy, participates in overall energy balance, and maintains intracellular homeostasis. ATP can act as an extracellular signaling molecule through interactions with specifi...		Endogenous Metabolite
T1638	N-Acetylneuraminic acid	Acide aceneuramique,NeuAc,Lactaminic acid	Others , Influenza Virus , Endogenous Metabolite
	N-Acetylneuraminic acid (Acide aceneuramique) is a nine-carbon sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells. Studies have shown t...		Others , Influenza Virus , Endogenous Metabolite
T26778	Besipirdine	HP 749 free base,P-867493,P867493,HP 749,HP749,P 867493	Sodium Channel , Adrenergic Receptor
	Besipirdine (HP 749 free base) is a non-receptor-dependent cholinomimetic compound with alpha-adrenergic and cardiovascular activities.Besipirdine inhibits voltage-dependent sodium-potassium channels and inhibits biogeni...		Sodium Channel , Adrenergic Receptor
T26778L	Besipirdine hydrochloride	HP 749 hydrochloride,Besipirdine hydrochloride（119257-34-0 Free base)	Adrenergic Receptor
	Besipirdine hydrochloride is a non-receptor-dependent cholinomimetic compound with alpha-adrenergic and cardiovascular activities.Besipirdine hydrochloride inhibits voltage-dependent sodium-potassium channels and inhibit...		Adrenergic Receptor
T1279	Vilazodone	SB659746A,EMD 68843	5-HT Receptor , Serotonin Transporter
	Vilazodone (SB659746A) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vilazodone inhibits the reuptake of serotonin from...		5-HT Receptor , Serotonin Transporter