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IDRA-21

Catalog No. T7823 CAS 22503-72-6

IDRA-21 is a positive AMPA receptor modulator.

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IDRA-21, CAS 22503-72-6

Pack Size	Availability	Price/USD
25 mg	In stock	$ 39.00
50 mg	In stock	$ 64.00
100 mg	In stock	$ 98.00
200 mg	In stock	$ 155.00
500 mg	In stock	$ 262.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 100%

Biological Description

Chemical Properties

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Description

IDRA-21 is a positive AMPA receptor modulator.

In vivo

Oral administration of IDRA 21 produced a highly significant improvement in the performance of a delayed matching-to-sample (DMTS) task by young adult rhesus monkeys.?The pattern of task improvement over the dose range 0.15-10 mg/kg was maintained to 48 hr after the single dose administration.?For sessions run after administration of the individualized Best Dose of IDRA 21, task accuracy for Long delay (most difficult) trials was increased by 34% of vehicle.?Animals were randomly assigned fixed doses of IDRA 21 to determine whether the positive mnemonic response could be maintained.?The repeated doses were separated by 3 days, thus allowing for potential cumulative effects.?IDRA 21 produced a gradual increase in task accuracy that was maintained on average above vehicle performance levels over an intermittent dosing schedule during a total period of 3 weeks.?A separate group of aged monkeys (>20 y) were, as a group, impaired (during vehicle testing) in DMTS performance efficiency relative to the young cohort.?IDRA 21 also improved task accuracy by aged rhesus monkeys over the same dose range, but the responses were not as robust as those exhibited by young animals.?Aged subjects also appeared to be more individually sensitive to drug dose, and they exhibited shorter task latencies than did the young group[1].

Molecular Weight	232.69
Formula	C8H9ClN2O2S
CAS No.	22503-72-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (107.44 mM)

References and Literature

1. Buccafusco J J , Weiser T , Winter K , et al. The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys[J]. Neuropharmacology, 2004, 46(1):10-22. 2. Losi G , Puia G , Braghiroli D , et al. IDRA-21, a positive AMPA receptor modulator, inhibits synaptic and extrasynaptic NMDA receptor mediated events in cultured cerebellar granule cells[J]. neuropharmacology, 2004, 46(8):1105-1113.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library Anti-Alzheimer's Disease Compound Library Neurotransmitter Receptor Compound Library Neuronal Signaling Compound Library Glutamine Metabolism Compound Library Bioactive Compounds Library Max NO PAINS Compound Library

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Keywords

IDRA-21 22503-72-6 Neuroscience GluR memory Inhibitor IDRA 21 inhibit orally active Ionotropic glutamate receptors aging excitatory neurotransmission cognitive GluR1/2 AMPA IDRA21 iGluR inhibitor

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