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Citalopram

Catalog No. T20828 CAS 59729-33-8

Synonyms: Cipram, Lu 10-171, Lu-10-171 Lu10-171

Citalopram (Lu 10-171 is an orally active, selective serotonin reuptake inhibitor (SSRI), a selective 5-hydroxytryptamine reuptake inhibitor, and a racemic mixture of the S(+)-enantiomer (Escitalopram) and the R(-)-enantiomer.Citalopram exhibits antidepressant activity and enhances serotonergic neurotransmission. It can be used to study Alzheimer's disease.

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Citalopram, CAS 59729-33-8

Pack Size	Availability	Price/USD
25 mg	In stock	$ 30.00
50 mg	In stock	$ 41.00
100 mg	In stock	$ 64.00
500 mg	In stock	$ 153.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.89%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Citalopram (Lu 10-171 is an orally active, selective serotonin reuptake inhibitor (SSRI), a selective 5-hydroxytryptamine reuptake inhibitor, and a racemic mixture of the S(+)-enantiomer (Escitalopram) and the R(-)-enantiomer.Citalopram exhibits antidepressant activity and enhances serotonergic neurotransmission. It can be used to study Alzheimer's disease.
In vitro	Citalopram exhibits concentration-dependent cytotoxicity when applied at concentrations ranging from 25 to 175 μM for 24 hours[4]. Specifically, at a concentration of 100 μM for 24 hours, Citalopram strongly downregulates the expression of MYBL2, BIRC5, BARD1, AURKA, CCNA2, and CCNE1 in B104 cells[4].
In vivo	Administered via intraperitoneal injection at doses ranging from 5 to 40 mg/kg, Citalopram reduces immobility time in DBA/2J mice but does not elicit a similar effect in C57BL/6J mice[3].

Synonyms	Cipram, Lu 10-171, Lu-10-171 Lu10-171
Molecular Weight	324.39
Formula	C20H21FN2O
CAS No.	59729-33-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL(246.62 mM), Sonication is recommended.

References and Literature

1. Carlsson B, et al. Enantioselective analysis of citalopram and escitalopram in postmortem blood together with genotyping for CYP2D6 and CYP2C19. J Anal Toxicol. 2009;33(2):65-76. 2. Milne RJ, et al. Citalopram. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. Drugs. 1991;41(3):450-477. 3. Zeng-Liang Jin, et al. Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function. Sci Rep. 2017 Aug 17;7(1):8631. 4. Laurent Sakka, et al. Assessment of citalopram and escitalopram on neuroblastoma cell lines. Cell toxicity and gene modulation. Oncotarget. 2017 Jun 27;8(26):42789-42807.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Drug Repurposing Compound Library Membrane Protein-targeted Compound Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library FDA-Approved Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Citalopram 59729-33-8 GPCR/G Protein Neuroscience 5-HT Receptor Cipram Lu 10-171 Lu-10-171 Lu10-171 inhibitor inhibit

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