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VUF 10166

VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.

Catalog No. T6728Cas No. 155584-74-0

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Purity:99.52%

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COA LCMS HPLC HNMR

VUF 10166

Catalog No. T6728Cas No. 155584-74-0

VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.

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Pack Size	Price	Availability
5 mg	$41	In Stock
10 mg	$66	In Stock
25 mg	$124	In Stock
100 mg	$332	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.
Targets&IC50	5-HT3A:0.04 nM(Ki)
In vitro	VUF10166 shows low activity to 5-HT3AB receptor with Ki of 22 nM. VUF10166 may be used to can distinguish between 5-HT3A and 5-HT3AB receptors. VUF10166 has no activity to α7 nACh receptor. VUF10166 also acts as a partial agonist at 5-HT3A receptors with EC50 of 5.2 μM, which shows that VUF10166 is unlikely to bind in the receptor pore. [1]

Chemical Properties

Molecular Weight	262.74
Formula	C₁₃H₁₅ClN₄
Cas No.	155584-74-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: 26.3 mg/mL (100 mM)

DMSO: 26.3 mg/mL (100 mM)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8060 mL	19.0302 mL	38.0604 mL	190.3022 mL
5 mM	0.7612 mL	3.8060 mL	7.6121 mL	38.0604 mL
10 mM	0.3806 mL	1.9030 mL	3.8060 mL	19.0302 mL
20 mM	0.1903 mL	0.9515 mL	1.9030 mL	9.5151 mL
50 mM	0.0761 mL	0.3806 mL	0.7612 mL	3.8060 mL
100 mM	0.0381 mL	0.1903 mL	0.3806 mL	1.9030 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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