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VUF 10166

VUF 10166
VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.
Catalog No. T6728Cas No. 155584-74-0
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Purity:99.52%
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VUF 10166

Catalog No. T6728Cas No. 155584-74-0
VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$41In Stock
10 mg$66In Stock
25 mg$124In Stock
100 mg$332In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.
Targets&IC50
5-HT3A:0.04 nM(Ki)
In vitro
VUF10166 shows low activity to 5-HT3AB receptor with Ki of 22 nM. VUF10166 may be used to can distinguish between 5-HT3A and 5-HT3AB receptors. VUF10166 has no activity to α7 nACh receptor. VUF10166 also acts as a partial agonist at 5-HT3A receptors with EC50 of 5.2 μM, which shows that VUF10166 is unlikely to bind in the receptor pore. [1]
Chemical Properties
Molecular Weight262.74
FormulaC13H15ClN4
Cas No.155584-74-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 26.3 mg/mL (100 mM)
DMSO: 26.3 mg/mL (100 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM3.8060 mL19.0302 mL38.0604 mL190.3022 mL
5 mM0.7612 mL3.8060 mL7.6121 mL38.0604 mL
10 mM0.3806 mL1.9030 mL3.8060 mL19.0302 mL
20 mM0.1903 mL0.9515 mL1.9030 mL9.5151 mL
50 mM0.0761 mL0.3806 mL0.7612 mL3.8060 mL
100 mM0.0381 mL0.1903 mL0.3806 mL1.9030 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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