neurodegenerative — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13486	Neurodegenerative Disorder-Targeting Compound 1		Others
	Neurodegenerative Disorder-Targeting Compound 1 is an inhibitor of calpain [1].		Others
T83527	(Rac)-Neurodegenerative Disorder-Targeting Compound 1
	(Rac)-Neurodegenerative Disorder-Targeting Compound 1 is a calpain inhibitor.
TC0039	Vasicinone		Others
	Vasicinone may act as a hepatoprotective agent. (±)-Vasicinone has significant antitussive, expectorant, and bronchodilating activities, which can be used to treat respiratory disease.(S)-Vasicinone exhibits antiprolifer...		Others
T21883	Gedunin		HSP
	Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer cell proliferation.		HSP
T1880	P7C3		Others
	The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, be...		Others
T8860	DSRM-3716		Androgen Receptor
	Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.		Androgen Receptor
TN6953	Lignoceric Acid	tetracosanoic acid	Endogenous Metabolite
	Lignoceric Acid (tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid and a by-product of lignin production, which is synthesized in the developing brain.		Endogenous Metabolite
T22043	BCATc Inhibitor 2		Others
	BCATc Inhibitor 2 exhibited an IC50 of 0.8 microM in the hBCATc assays; it is an active and selective inhibitor. BCATc Inhibitor 2 also blocked calcium influx into neuronal cells following inhibition of glutamate uptake,...		Others
T8849	PF-9601N		MAO
	PF-9601N showed high potency and selectivity as a MAO-BI (monoamine oxidase type B inhibitor) and also demonstrated remarkable neuroprotective properties in several in vivo and cellular models of PD.		MAO
T35856	BMS-986176		AAK1 (AP2 associated kinase 1)
	AAK1-IN-1 (example 123) is an AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2.2 nM. AAK1-IN-1 can be used for neurodegenerative diseases research[1]. Adaptor associated kinase 1 (AAK1) is a member of the A...		AAK1 (AP2 associated kinase 1)
T11095L	DREADD agonist 21		5-HT Receptor , Adrenergic Receptor , AChR , Histamine Receptor
	DREADD agonist 21 is a potent agonist of human muscarinic acetylcholine M3 receptors (EC50=1.7 nM).
T6S1653	Albiflorin	Alibiflorin	Reactive Oxygen Species
	1. Albiflorin (Alibiflorin) has anticonvulsant effect for pain relief. 2. Albiflorin and paeoniflorin has neuroprotective action against Glu toxicity. 3. Albiflorin and paeoniflorin significantly ameliorated Glu-induced ...		Reactive Oxygen Species
T14080	AA147	ATF6-activator-147	Others
	AA147 (ATF6-activator-147) is a small molecule endoplasmic reticulum (ER) proteostasis regulator. The selectively activates ATF6 arm of the unfolded protein response (UPR) .It acts as a prodrug that preferentially trigge...		Others
T3707	GNE-3511	GNE3511	DNA Alkylation , MAPK
	GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.		DNA Alkylation , MAPK
T9272	Xaliproden hydrochloride		Dopamine Receptor , 5-HT Receptor
	Xaliproden is a compound that mimics the effects of nerve growth factor and is also a serotonin 5-HT1A receptor agonist.		Dopamine Receptor , 5-HT Receptor
TN2004	Obtusin		MAO , Monoamine Oxidase
	Obtusin is a natural product.		MAO , Monoamine Oxidase
T7426	ALSTERPAULLONE		Apoptosis , GSK-3 , CDK
	Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec		Apoptosis , GSK-3 , CDK
T5728	OsMundacetone	4-(3,4-Dihydroxyphenyl)-3-buten-2-one	Apoptosis , Reactive Oxygen Species
	OsMundacetone (4-(3,4-Dihydroxyphenyl)-3-buten-2-one) is a natual product isolated from Rhizoma osmundae.		Apoptosis , Reactive Oxygen Species
T9611	PF-04802367		GSK-3
	PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. It shows desirable central nervous system (CNS) properties and ...		GSK-3
T0086	Galanthamine hydrobromide	Galantamine hydrobromide,Galanthamine HBr	AChR , AChE
	Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.		AChR , AChE