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Galanthamine hydrobromide

Catalog No. T0086 CAS 1953-04-4

Synonyms: Galanthamine HBr, Galantamine hydrobromide

Galanthamine hydrobromide, a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.

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Galanthamine hydrobromide, CAS 1953-04-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Galanthamine hydrobromide, a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
Targets&IC50	AChE:410 nM
In vitro	Galanthamine has been demonstrated to have an IC50 of 14 nM and 15 nM on AChE in post-mortem human brain frontal cortex and the hippocampus region. Red-cell cholinesterase activity in blood samples from the neurosurgery patients is 10 times more strongly inhibited by Galanthamine in brain tissue samples. [1] Galanthamine (1 μM) activates single channels with conductance's of 18 and 30 pS in outside-out patches excised from dexamethasone mouse fibroblasts (M10 cells). [2] Galanthamine acts as noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma (PC12) cells. Galanthamine (50 μM) activates single-channel currents in outside-out patches excised from clonal PC12 cells. [3]
In vivo	Galantamine significantly increases the number of living pyramidal neurons after ischemia-reperfusion injury. Galantamine significantly reduces TUNEL, active caspase-3, and SOD-2 immunoreactivity. The nicotinic antagonist mecamylamine blockes the protective effects of galantamine. The neuroprotective effects of galantamine are preserved even when first administered at 3 hours postischemia. [4]

Synonyms	Galanthamine HBr, Galantamine hydrobromide
Molecular Weight	368.27
Formula	C17H21NO3·HBr
CAS No.	1953-04-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 7.4 mg/mL (20 mM)), with gentle warming

H2O: 7.4 mg/mL (20 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Thomsen T, et al. Eur J Clin Chem Clin Biochem, 1991, 29(8), 487-492. 2. Pereira EF, et al. J Pharmacol Exp Ther, 1994, 270(2), 768-778. 3. Storch A, et al. Eur J Pharmacol, 1995, 290(3), 207-219. 4. Lorrio S, et al. J Pharmacol Exp Ther, 2007, 322(2), 591-599.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Galanthamine hydrobromide 1953-04-4 Neuroscience AChR AChE disease neurodegenerative Inhibitor nAChR Nicotinic acetylcholine receptors disease (AD) Cholinesterase (ChE) acetylcholinesterase Galanthamine HBr Galantamine hydrobromide inhibit Galantamine Alzheimer's Galanthamine inhibitor

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