Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Galanthamine hydrobromide, a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
Description | Galanthamine hydrobromide, a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors. |
Targets&IC50 | AChE:410 nM |
In vitro | Galanthamine has been demonstrated to have an IC50 of 14 nM and 15 nM on AChE in post-mortem human brain frontal cortex and the hippocampus region. Red-cell cholinesterase activity in blood samples from the neurosurgery patients is 10 times more strongly inhibited by Galanthamine in brain tissue samples. [1] Galanthamine (1 μM) activates single channels with conductance's of 18 and 30 pS in outside-out patches excised from dexamethasone mouse fibroblasts (M10 cells). [2] Galanthamine acts as noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma (PC12) cells. Galanthamine (50 μM) activates single-channel currents in outside-out patches excised from clonal PC12 cells. [3] |
In vivo | Galantamine significantly increases the number of living pyramidal neurons after ischemia-reperfusion injury. Galantamine significantly reduces TUNEL, active caspase-3, and SOD-2 immunoreactivity. The nicotinic antagonist mecamylamine blockes the protective effects of galantamine. The neuroprotective effects of galantamine are preserved even when first administered at 3 hours postischemia. [4] |
Synonyms | Galanthamine HBr, Galantamine hydrobromide |
Molecular Weight | 368.27 |
Formula | C17H21NO3·HBr |
CAS No. | 1953-04-4 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 7.4 mg/mL (20 mM)), with gentle warming
H2O: 7.4 mg/mL (20 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Galanthamine hydrobromide 1953-04-4 Neuroscience AChR AChE disease neurodegenerative Inhibitor nAChR Nicotinic acetylcholine receptors disease (AD) Cholinesterase (ChE) acetylcholinesterase Galanthamine HBr Galantamine hydrobromide inhibit Galantamine Alzheimer's Galanthamine inhibitor