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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T16695 | Pyrintegrin | Integrin | |
Pyrintegrin is an β1-integrin agonist that promotes embryonic stem cells' survival. Pyrintegrin can be used as a podocyte-protective agent. Pyrintegrin enhances cell-extracellular matrix adhesion-mediated integrin signal... | |||
TN1644 | Flavanomarein | Others | |
Flavanomarein demonstrates potent antioxidative property, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid-lowering effects in human HepG2 hepatocellular carcinoma cells trea... | |||
T16724 | Razuprotafib | AKB-9778 | Phosphatase , Others |
Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor (IC50: 50 nM). Razuprotafib is effective for the activation of Tie-2 and is protective against acute kidney injury. | |||
T14002 | 12-Ketodeoxycholic acid | Endogenous Metabolite | |
12-Ketodeoxycholic acid, a bile acid and kidney metabolite, serves as a detectable marker for kidney injury [1]. | |||
T0476 | Spironolactone | SC9420,Abbolactone | Glucocorticoid Receptor , Androgen Receptor , Autophagy |
Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist. | |||
T8408 | GKT136901 | AK120765 | NADPH-oxidase , NADPH |
GKT136901 (AK120765) is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite | |||
T6542 | Imidapril hydrochloride | Novaloc,Imidapril HCl,Tanapril,TA-6366 | RAAS |
Imidapril hydrochloride (Tanapril) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension. | |||
TN1471 | Cassiaside C | Toralactone 9-O-β-D-gentiobioside | Others , Endogenous Metabolite |
Cassiaside C (Toralactone 9-O-β-D-gentiobioside), a naphthopyrone extracted from Cassia tora seeds, exhibits in vitro inhibitory activity against the formation of advanced glycation end products (AGE). | |||
T28360 | PF-00489791 | PF-4634817,PF 4634817,PF00489791,PF 00489791,PF4634817 | PDE |
PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy. | |||
T6486 | Enalapril Maleate | MK-421 Maleate,Renitec Maleate,Glioten Maleate,MK-421 (maleate),Vasotec Maleate | RAAS |
Enalapril Maleate (MK-421 Maleate), an angiotensin-converting enzyme (ACE) inhibitor, is utilized in the treatment of hypertension, chronic heart failure , and diabetic nephropathy. | |||
TP1761L | Handle region peptide, rat acetate | Handle region peptide, rat acetate(749227-53-0 free base) | Others |
Handle region peptide, rat acetate is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye. | |||
T24626 | PF-249 | PF-06685249,PF 06685249,PF06685249 | AMPK |
PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy. | |||
T0358 | Aminoguanidine hydrochloride | Imino semicarbazide,Pimagedine hydrochloride,CP-12009-18 tartrate,Hydrazinecarboximidamide,Guanyl hydrazine,Pimagedine | NOS , NO Synthase |
Aminoguanidine hydrochloride (Hydrazinecarboximidamide) is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy. | |||
TP1978L | NFAT inhibitor, Cell Permeable aceate | Others | |
NFAT inhibitor, Cell Permeable aceate is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. It can be used for the research of podocyte and diabetic nephropathy. | |||
T6S1367 | Procyanidin B2 | Proanthocyanidin B2 | Reactive Oxygen Species , NOD |
Procyanidin B2 (Proanthocyanidin B2) has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression ... | |||
T0778 | Phenacetin | Acetophenetidin | COX |
Phenacetin (Acetophenetidin) is a phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market. | |||
T14301 | Apararenone | MT-3995 | Glucocorticoid Receptor |
Apararenone (MT-3995) is a receptor antagonist of mineralocorticoid receptor which can be used to treat non-alcoholic steatohepatitis and diabetic nephropathy. | |||
TL0001 | Dencichine | L-Dencichin,ODAP,Dencichin | Others , HIF/HIF Prolyl-Hydroxylase |
Dencichine (ODAP) is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation and fibrinolytic system. It has renoprotective effec... | |||
T24270 | KS370G | KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide | |
KS370G (Caffeic Acid Phenethyl Amide) inhibits UUO-induced renal fibrosis marker expression. KS370G is an orally active hypoglycemic and cardioprotective agent that reduces collagen deposition in obstructed kidneys and s... | |||
T35689 | MTP 131 acetate | Others | |
MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging... |