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MTP 131 acetate

Catalog No. T35689 CAS 1334953-95-5

MTP 131 (acetate) is a small mitochondrially-targeted tetrapeptide.

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MTP 131 acetate, CAS 1334953-95-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 68.00
2 mg	In stock	$ 98.00
5 mg	In stock	$ 133.00
10 mg	In stock	$ 213.00
25 mg	In stock	$ 375.00
50 mg	In stock	$ 557.00
100 mg	In stock	$ 783.00
500 mg	In stock	$ 1,660.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	MTP 131 (acetate) is a small mitochondrially-targeted tetrapeptide.
In vitro	Pretreatment of cells with MTP 131 (acetate) inhibited H2O2?induced cytotoxicity and reduced LDH release in a dose?dependent manner, compared with cells treated with H2O2 alone. Mitochondrial depolarization and ROS generation were also prevented by MTP 131 (acetate) pretreatment. In addition, MTP 131 (acetate) pretreatment inhibited cytochrome c release from mitochondria to cytoplasm, and significantly reduced apoptosis in RGC?5 cells, compared with cells treated with H2O2 alone[1].
In vivo	18-week-old db/db mice have reduced renal and cardiac superoxide levels, as measured by dihydroethidium oxidation, and increased levels of albuminuria, mesangial matrix accumulation, and urinary H2O2 Administration of MTP 131 (acetate) significantly inhibited increases in albuminuria, urinary H2O2, and mesangial matrix accumulation in db/db mice and fully preserved levels of renal superoxide production in these mice. MTP 131 (acetate) also reduced total renal lysocardiolipin and major lysocardiolipin subspecies and preserved lysocardiolipin acyltransferase 1 expression in db/db mice[1].

Molecular Weight	699.84
Formula	C34H53N9O7
CAS No.	1334953-95-5

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

PBS (pH 7.2): 10 mg/mL

References and Literature

1. Chen M, et al. Protective effect of mitochondria‑targeted peptide MTP‑131 against oxidative stress‑induced apoptosis in RGC‑5 cells. Mol Med Rep. 2017 Apr;15(4):2179-2185. 2. Miyamoto S, Zhang G, Hall D, Oates PJ, Maity S, Madesh M, Han X, Sharma K. Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease. J Biol Chem. 2020 May 22;295(21):7249-7260. doi: 10.1074/jbc.RA119.011110. Epub 2020 Apr 10. PMID: 32277051; PMCID: PMC7247302. 3. Miyamoto, S., Zhang, G., Hall, D., et al.Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney diseaseJ. Biol. Chem.295(21)7249-7260(2020)

Related compound libraries

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MTP 131 acetate 1334953-95-5 Others MTP131 Acetate MTP 131 Acetate MTP-131 Acetate inhibitor inhibit

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