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Aminoguanidine hydrochloride

Catalog No. T0358 CAS 1937-19-5

Synonyms: Imino semicarbazide, Pimagedine hydrochloride, CP-12009-18 tartrate, Hydrazinecarboximidamide, Guanyl hydrazine, Pimagedine

Aminoguanidine hydrochloride (Hydrazinecarboximidamide) is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Aminoguanidine hydrochloride Chemical Structure

Aminoguanidine hydrochloride, CAS 1937-19-5

Pack Size	Availability	Price/USD
50 mg	In stock	$ 36.00
100 mg	In stock	$ 50.00
200 mg	In stock	$ 75.00
500 mg	In stock	$ 119.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

Biological Description

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Storage & Solubility Information

Description

Aminoguanidine hydrochloride (Hydrazinecarboximidamide) is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.

In vivo

Aminoguanidine ameliorates neonatal hypoxic-ischemic brain damage and that temporal profiles of NO correlated with the neuroprotective effect of aminoguanidine. Neuroprotection by AG is attributable to suppression of NO produced by iNOS after the end of the hypoxic period, during the reoxygenation phase. The half-life of AG is estimated to be between 6 and 8 h in vivo and approximately 4.4 h in human with normal renal function.AG is also an inhibitor of the formation of advanced glycation end products. Systematically administered advanced glycation end product–modified BSA increases cerebral infarct size in an adult rat, which is attenuated by AG[2].

Synonyms	Imino semicarbazide, Pimagedine hydrochloride, CP-12009-18 tartrate, Hydrazinecarboximidamide, Guanyl hydrazine, Pimagedine
Molecular Weight	110.55
Formula	CH6N4·HCl
CAS No.	1937-19-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 21 mg/mL (190 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: 20 mg/mL (180.9 mM)

References and Literature

1. Rokkas T, et al. Digestion. 1990, 46 Suppl 2:447-457. 2. Tsuji M, et al. Pediatr Res. 2000, 47(1):79-83. 3. Brownlee M, et al. Science. 1986, 232(4758):1629-1632.

Citations

1. Bi G, Liang J, Bian Y, et al.Polyamine-mediated ferroptosis amplification acts as a targetable vulnerability in cancer.Nature Communications.2024, 15(1): 2461.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library FDA-Approved Drug Library Anti-Aging Compound Library Approved Drug Library NO PAINS Compound Library Nonsteroidal Anti-Inflammatory Compound Library Immunology/Inflammation Compound Library Target-Focused Phenotypic Screening Library FDA-Approved & Pharmacopeia Drug Library

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Keywords

Aminoguanidine hydrochloride 1937-19-5 Immunology/Inflammation NOS NO Synthase Aminoguanidine Hydrochloride Nitric oxide synthases GER 11 GER-11 Imino semicarbazide Pimagedine hydrochloride CP-12009-18 tartrate Hydrazinecarboximidamide Aminoguanidinium CP-12009-18 Tartrate inhibit GER11 Inhibitor Pimagedine Hydrochloride Guanyl hydrazine Pimagedine Aminoguanidine inhibitor

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