multidrug — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9982	PU23		MRP
	PU 23 is an inhibitor of multidrug-resistant protein 4 (MRP4).		MRP
T11888	LtaS-IN-1		Others , Antibacterial
	LtaS-IN-1 is an effective inhibitor of Lipoteichoic acid synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 is against Enterococcus spp 28 strains with varying MIC value...		Others , Antibacterial
TN1651	Furanodiene		Apoptosis , PARP , Reactive Oxygen Species , Caspase , CDK , P-gp
	Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
T3S0012	Coniferyl ferulate		P-gp , GST
	Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental GST (IC50: 0.3 μM). It also reverses multidrug resistance ...		P-gp , GST
T1248	Sulfanitran		Antibacterial , Autophagy
	Sulfanitran is a sulfonamide antibiotic used in the poultry industry.		Antibacterial , Autophagy
T8596	Ceefourin 1		MRP
	Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.		MRP
T1631	Sulbactam	CP45899	Antibacterial , Antibiotic
	Sulbactam (CP45899) is a semi-synthetic beta-lactamase inhibitor. The beta-lactam ring of sulbactam irreversibly binds to beta-lactamase at or near its active site, thereby blocking enzyme activity and preventing metabol...		Antibacterial , Antibiotic
T2S0223	Isosinensetin	6-Demethoxynobiletin	Antioxidant , HIV Protease , Antibacterial , P-gp
	1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.		Antioxidant , HIV Protease , Antibacterial , P-gp
T6685	Sulbactam sodium	CP-45899-2	Antibacterial , Antibiotic
	Sulbactam sodium (CP-45899-2) (Unasyn) is an irreversible β-lactamase inhibitor.		Antibacterial , Antibiotic
T8426	Encequidar	HM30181,HM30181A	P-gp
	Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.		P-gp
TN4761	Phellamurin		P-gp
	Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadmini...		P-gp
T12341	P-gp inhibitor 1		Others , P-gp
	P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).		Others , P-gp
T10460	Batabulin	T138067	Apoptosis , Microtubule Associated
	Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to ce...		Apoptosis , Microtubule Associated
T2S0271	Voacamine	Voacanginine	Cannabinoid Receptor , P-gp
	Voacamine (Voacanginine) is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells.Voacangini...		Cannabinoid Receptor , P-gp
TJS1159	Chrysosplenetin	Chrysosptertin B	P450 , Ferroptosis , P-gp
	Chrysosplenetin is a metabolic inhibitor of artemisinin.		P450 , Ferroptosis , P-gp
T16561	Polyoxyethylene stearate	POES	Antibacterial , P-gp
	Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.		Antibacterial , P-gp
T3002	Piperine	1-Piperoylpiperidine,Bioperine	P450 , Endogenous Metabolite , P-gp , Autophagy
	Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.		P450 , Endogenous Metabolite , P-gp , Autophagy
T11071	Dofequidar fumarate	MS-209	P-gp
	Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the inhibition of ABCB1/P-glycoprotein (P-gp) and ABCC1/MDR-ass...		P-gp
T6287	Tariquidar	XR9576	P-gp
	Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.		P-gp
T4989	Fosfomycin Tromethamine		Antibacterial , Antibiotic
	An antibiotic produced by Streptomyces fradiae.		Antibacterial , Antibiotic