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LtaS-IN-1

Catalog No. T11888 CAS 877950-01-1

LtaS-IN-1 is an effective inhibitor of Lipoteichoic acid synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 is against Enterococcus spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 inhibits strain E1630 and E1590 with MIC values of 0.5 μg/mL.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

LtaS-IN-1, CAS 877950-01-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 178.00
25 mg	In stock	$ 313.00
50 mg	In stock	$ 488.00
100 mg	In stock	$ 716.00
1 mL * 10 mM (in DMSO)	In stock	$ 133.00

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Purity: 91.75%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LtaS-IN-1 is an effective inhibitor of Lipoteichoic acid synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 is against Enterococcus spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 inhibits strain E1630 and E1590 with MIC values of 0.5 μg/mL.
Targets&IC50	Strain E1630:0.5 μg/mL (MIC), Strain E1590:0.5 μg/mL (MIC)
In vitro	LtaS-IN-1 (20 μM) combines with either ampicillin (20 μg/mL), gentamicin (10 μg/mL), linezolid (5 μg/mL), daptomycin (10 μg/mL+50 μg/mL calcium chloride) or vancomycin (20 μg/mL) can inhibit strains E7128 and E7130 growth by 97-100%, while LtaS-IN-1 alone only gives 73% (strain E7128) and 8% (strain E7130) of growth inhibition, respectively. LtaS-IN-1 (0-100 μM) inhibits strain E745 growth as a concentration-dependent manner. LtaS-IN-1 (10 μM) leads to a 60% reduction in the final OD600 for this strain. Meanwhile, LtaS-IN-1 does not affect E. faecium growth in control group[1].

Molecular Weight	427.41
Formula	C24H17N3O5
CAS No.	877950-01-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (280.76 mM), Sonication is recommended.

References and Literature

1. Paganelli FL, et al. Lipoteichoic acid synthesis inhibition in combination with antibiotics abrogates growth of multidrug-resistant Enterococcus faecium.Int J Antimicrob Agents. 2017 Mar;49(3):355-363.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Bacterial Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LtaS-IN-1 877950-01-1 Microbiology/Virology Others Antibacterial Bacterial MDR E. faecium LtaSIN1 multidrug-resistant inhibit LtaS IN 1 anti-bacterial Inhibitor inhibitor

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