mitotic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN7041	(-)-Epipodophyllotoxin		Apoptosis
	(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vit...		Apoptosis
TN2190	Scoulerine		Apoptosis , Beta-Secretase , BACE , Parasite
	Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.		Apoptosis , Beta-Secretase , BACE , Parasite
T60026	KIF18A-IN-2		Microtubule Associated
	KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities.		Microtubule Associated
T21351	Maytansine	NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine	Microtubule Associated , Antibiotic
	Maytansine (NSC-153858), an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.		Microtubule Associated , Antibiotic
T8492	BO-264		Apoptosis , FGFR
	BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).		Apoptosis , FGFR
T9595	LP-261		Microtubule Associated
	LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.		Microtubule Associated
T9521	CHR-6494 TFA		Others
	CHR-6494 TFA is a potent haspin inhibitor, with an IC50 of 2 nM. It inhibits histone H3T3 phosphorylation. CHR-6494 TFA induces the apoptosis of cancer cells, including melanoma and breast cancer. CHR-6494 TFA can be use...		Others
TQ0317	R1530	R-1530,R 1530	VEGFR , FGFR , FLT , PDGFR
	R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.		VEGFR , FGFR , FLT , PDGFR
T8342	BRD9876		Others , Kinesin , Microtubule Associated
	BRD9876 is a selective inhibitor of MM1S growth.		Others , Kinesin , Microtubule Associated
T16156	MT 63-78		Apoptosis , AMPK , mTOR
	MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects. MT 63–78 also causes cel...		Apoptosis , AMPK , mTOR
T19720	Colcemid	C 12669,C-12669,NSC-3096,Kolchicin,C12669,Demecolcine	Microtubule Associated
	Colcemid (NSC-3096) is an inhibitor of microtubule polymerization. It used to study embryonic cloning.		Microtubule Associated
T6019	Volasertib	BI 6727	Apoptosis , PLK
	Volasertib (BI 6727) (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM), inducing mitotic arrest and apoptosis. It also inhibits PLK2/PLK3 (IC50s: 5/56 nM).		Apoptosis , PLK
T9083	TC11	CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11	BCL , Caspase , CDK
	TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.		BCL , Caspase , CDK
T2241	Alisertib	MLN 8237	Apoptosis , Aurora Kinase , Autophagy
	Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.		Apoptosis , Aurora Kinase , Autophagy
T6393	ARQ 621		Kinesin
	ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.		Kinesin
T3330L	Cis-trismethoxy Resveratrol	(Z)-3,5,4'-Trimethoxystilbene	Microtubule Associated
	cis-trismethoxy Resveratrol ((Z)-3,5,4'-Trimethoxystilbene) inhibits tubulin polymerization (IC50 = 4 μM) and has anti-mitotic effects.		Microtubule Associated
T22455	Vindesine sulfate	DVA,Desacetylvinblastine amide,DAVA,Desacetyl Vinblastine amide,VDS	Others
	Vindesine sulfate (Desacetyl Vinblastine amide) is a vinca alkaloid which is a synthetic derivative of vinblastine, binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule...		Others
T4029	BTB-1	BTB 1,NSC156750	Microtubule Associated
	BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A.		Microtubule Associated
T20506	Maleuric acid	N-Carbamoylmaleamic acid,AI3 32778,AI3-32778,AI332778	Others
	Maleuric acid (N-Carbamoylmaleamic acid) is anti-mitotic and can be used in biological research in conjunction with radioautography.Maleuric acid is used to improve the growth and fertility of plants and animals as well ...		Others
T4048	Monastrol	(±)-Monastrol	Apoptosis , Kinesin
	Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.		Apoptosis , Kinesin