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ARQ 621

Catalog No. T6393   CAS 1095253-39-6

ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.

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ARQ 621 Chemical Structure
ARQ 621, CAS 1095253-39-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 78.00
2 mg In stock $ 113.00
5 mg In stock $ 192.00
10 mg In stock $ 285.00
25 mg In stock $ 483.00
50 mg In stock $ 689.00
100 mg In stock $ 958.00
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Purity: 98.38%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
In vitro ARQ 621 demonstrates anti-tumor activity against a wide range of human cancer cell lines in vitro, including colon, lung, endometrial, bladder, and hematologic cancer cell lines, with significantly less cytotoxicity against hematopoietic cells. [1]
In vivo ARQ 621, as a novel clinical stage drug candidate, inhibits a number of xenografts grown in athymic mice, such as pancreatic, breast, prostate, and ovarian carcinomas with no hematological changes. Furthermore, for ARQ 621, there is no envidence of bone marrow toxicity in pre-clinical mouse efficacy models or safety studies in rats and dogs. [1]
Molecular Weight 552.43
Formula C28H24Cl2FN5O2
CAS No. 1095253-39-6

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 93 mg/mL (168.3 mM)

DMSO: 93 mg/mL (168.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Rosen L, et al. Annual Meeting of ASCO: abstract 3076

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Bioactive Compound Library Bioactive Compounds Library Max Cytoskeletal Signaling Pathway Compound Library NO PAINS Compound Library Inhibitor Library Clinical Compound Library Drug Repurposing Compound Library

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Keywords

ARQ 621 1095253-39-6 Cytoskeletal Signaling Kinesin motor inhibit cell division ARQ621 protein Inhibitor microtubule Anti-tumor Eg5 ARQ-621 inhibitor

 

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