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MT 63-78

Catalog No. T16156 CAS 1179347-65-9

MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects. MT 63–78 also causes cell mitotic arrest and apoptosis.

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MT 63-78, CAS 1179347-65-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 78.00
2 mg	In stock	$ 112.00
5 mg	In stock	$ 172.00
10 mg	In stock	$ 289.00
25 mg	In stock	$ 489.00
50 mg	In stock	$ 686.00
100 mg	In stock	$ 969.00
1 mL * 10 mM (in DMSO)	In stock	$ 193.00

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Purity: 98.03%

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Description	MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects. MT 63–78 also causes cell mitotic arrest and apoptosis.
Targets&IC50	AMPK:25 μM (EC50), mTORC1:
In vitro	MT 63-78 (0-50 μM; 24 hours; LNCaP, PC3, C4-4, C4-2B, CL1and 22RV1cells) treatment induces reduction of anti-apoptotic Mcl-1 in concert with an accumulation of the pro-apoptotic BH3-only protein Puma. MT 63-78 (0-50 μM; 4 days; LNCaP and PC3 cells) treatment displays a dose-dependent decrease in cell number and concomitant to the activation of AMPK signaling. MT 63-78 (0-50 μM; 30 minutes; LNCaP and PC3 cells) treatment shows dose-dependent phosphorylation of the two major AMPK targets Acetyl-CoA Carboxylase (ACC) on Ser79 and of Raptor on Ser792. And also increases Thr172 phosphorylation on the AMPK α subunit. MT 63-78 (25 μM; 24 hours; LNCaP and CRPC cells) treatment causes a significant enrichment in the G2/M population .
In vivo	MT 63-78 (30 mg/kg; intraperitoneal injection; daily; for 14 days; C57 BL/6 male mice) treatment causes a 33% inhibition of tumor growth.

Molecular Weight	326.35
Formula	C21H14N2O2
CAS No.	1179347-65-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.26 mg/mL (10 mM)

References and Literature

1. Zadra G, et al. A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis. EMBO Mol Med. 2014 Apr;6(4):519-38.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Prostate Cancer Compound Library Anti-Hypertension Compound Library Epigenetics Compound Library Autophagy Compound Library Anti-Colorectal Cancer Compound Library Anti-Liver Cancer Compound Library Neural Regeneration Compound Library Glutamine Metabolism Compound Library Anti-Breast Cancer Compound Library

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Keywords

MT 63-78 1179347-65-9 Apoptosis Chromatin/Epigenetic PI3K/Akt/mTOR signaling AMPK mTOR Raptor mitotic Mammalian target of Rapamycin direct antitumor Thr172 arrest dephosphorylation Inhibitor AMP-activated protein kinase Mcl-1 mTORC1 MT 63 78 lipogenesis BH3 MT 6378 p53 inhibit inhibitor

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