interactions — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1199	Mitotane	Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD	Apoptosis , AChR
	Mitotane (NCI-C04933) is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors a...		Apoptosis , AChR
T2544	Bazedoxifene acetate	WAY-TES 424,TSE 424,WAY-140424	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Bazedoxifene acetate (WAY-TES 424) is a novel selective estrogen receptor modulator (SERM).		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T6404	Bazedoxifene hydrochloride	Bazedoxifene HCl,TSE-424	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Bazedoxifene hydrochloride (TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively.		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T9184L	Compound 3344 hydrochloride	4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline hydrochloride(2368246-78-8 free base),Compound 3344 hydrochloride (2368246-78-8 free base)	Ras
	Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.		Ras
T40370	2′-Deoxyadenosine 5′-monophosphate disodium		Endogenous Metabolite
	2′-Deoxyadenosine 5′-monophosphate disodium, a nucleic acid AMP derivative, is a deoxyribonucleotide present in DNA. It is employed for researching adenosine-based interactions within DNA synthesis and damage analysis.		Endogenous Metabolite
TN1513	Clitorin		PKC , Antifection
	Clitorin has free radical scavenging property. It shows significant interactions with CD38, it may have anti-hyperglycemic potential.		PKC , Antifection
T60006	Aromatase inhibitor 23		Others
	Aromatase inhibitor 23 is an inhibitor that target protein-protein interactions in RAD51 family of recombinases.		Others
T9039	HIV-1 Nef-IN-1		HIV Protease
	HIV-1 Nef-IN-1 is an inhibitor of HIV-1 Nef protein. It efficiently competes for Nef-SH3Hck interactions(Kd : 6.7 μM).		HIV Protease
T36411	9-Ethylguanine		Others
	9-Ethylguanine is a model nucleobase that is used to study DNA interactions with organometallic complexes, especially those designed to target tumors.		Others
T9544	Compound 1T-0216		Others
	Compound 1T-0216 is a blocker of AKT1-FAK interactions and reduces stimulation of FAK phosphorylation by extracellular stress in human SW620 colon cancer cells without affecting basal FAK phosphorylation.		Others
T9954	K-975		Others
	K-975 is a highly selective, orally active TEAD inhibitor, effectively inhibiting protein-protein interactions between TEAD and YAP1/TAZ.		Others
T3797	Isosilybin	Isosilybinin,Isosilibinin,Silymarin,Silybin B,Q-100795	P450
	Isosilybin (Isosilibinin) and Silybin might be suitable candidates to design potent PXR antagonists to prevent drug-drug interactions via CYP3A4 in cancer patients.		P450
T3635	IQ 1	IQ1,IQ-1	Wnt/beta-catenin
	IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions, and so on.		Wnt/beta-catenin
T9109	SSAA09E2		RAAS , SARS-CoV
	SSAA09E2 is a new SARS-CoV replication inhibitor, acting by blocking early interactions of SARS-S with the receptor for SARS-CoV, Angiotensin Converting Enzyme-2 (ACE2).		RAAS , SARS-CoV
T6023	Nutlin-3a	(-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3	Apoptosis , E1/E2/E3 Enzyme , Autophagy
	Nutlin-3a ((−)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein.		Apoptosis , E1/E2/E3 Enzyme , Autophagy
T38170	RMC-0331	RM-023	Raf
	RMC-0331 (RM-023) is an orally available and potent SOS1 inhibitor.RMC-0331 has potential anticancer activity, blocking RAS activation by disrupting RAS-SOS1 interactions.		Raf
T7570	RGD peptide (GRGDNP)	RGD peptide GRGDNP(2TFA),RGD peptide GRGDNP	Apoptosis , Integrin
	RGD peptide (GRGDNP) (RGD peptide GRGDNP(2TFA)) is a integrin-ligand interactions inhibitor.		Apoptosis , Integrin
T77695	Muvalaplin	LY3473329	Others
	Muvalaplin (LY3473329) is an orally active lipoprotein (a) Lp(a) reagent that inhibits Lp(a) formation by blocking apo(a)-apo B100 interactions.		Others
T60081	BV02	2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxoisoindoline-5-carboxylic acid	Others
	BV02 is an inhibitor of 14-3-3 protein-protein interactions and can be used in studies about the treatment of chronic myeloid leukemia. BV02 disrupts hematopoietic cells expressing the IM-resistant T315I mutation and the...		Others
T65550	Gefitinib analog III	4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate	Others
	Gefitinib analog III (4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate) has potential anti-inflammatory and anti-tumor activity and can be used to study its interactions and activity in organisms.		Others