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Search Results for " homodimer "

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T75375	Acridine homodimer
	Acridine Homodimer (NSC 219743), also known as acridine dimer, serves as a fluorescent dye that exhibits blue-green fluorescence upon binding to DNA. This compound demonstrates a significantly high affinity for AT-rich r...
T31696	EthD-1	EthD1,Ethidium Homodimer-1
	EthD-1 is a cell-impermeant viability indicator. It acts as a high-affinity nucleic acid stain.
T13547L	AMP-PCP disodium		HSP
	AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM. The binding of AMP-PCP disodium contributes to the formation of an active homodimer of Hsp90.		HSP
T13063	T6167923		MyD88
	T6167923 is a potent, selective inhibitor of MyD88-dependent signaling pathways. It achieves this by directly binding to the Toll/IL1 receptor (TIR) domain of MyD88, preventing MyD88 homodimer formation. Subsequently, T6...		MyD88
T25006	AGI-14100	AGI 14100	Dehydrogenase
	AGI-14100 is a novel and orally available mIDH1 inhibitor.AGI-14100 is used for the treatment of primary human myeloid leukemia.		Dehydrogenase
T71203	JBIR-22
	JBIR-22 is a natural inhibitor for protein−protein interaction of the homodimer of proteasome assembly factor 3.
T13547	AMP-PCP		HSP
	AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.		HSP
T28962	Thielocin B1	Thielocin-B1
	Thielocin B1 is a protein-protein interaction inhibitor of PAC3 homodimer. Thielocin B1 was isolated as a novel phospholipase A2 inhibitor from the fermentation broth of Thielavia terricola RF-143.
T15748	LG100754	UVI 2112	PPAR
	LG100754 (UVI 2112) is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functions as an agonist towards RXR: PPARα and RXR: PPAR...		PPAR
T78869	TWIK-1/TREK-1-IN-2		Potassium Channel
	TWIK-1/TREK-1-IN-2 (Compound 2g) serves as an inhibitor of both TWIK-1 and TREK-1, targeting the TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50 values of 10.13 μM and 15.5 μM, respectively. Additionally, it exh...		Potassium Channel
T65994	(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
	Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a ...

Compounds

Synonym: EthD1,Ethidium Homodimer-1

Target: Dehydrogenase

Synonym: Thielocin-B1

Target: Potassium Channel

(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

T65994

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T1168	Desonide	Tridesilon,Locapred,Prednacinolone	Glucocorticoid Receptor
	Desonide (Prednacinolone) is a synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated ...		Glucocorticoid Receptor

Natural Products

Desonide

T1168

Synonym: Tridesilon,Locapred,Prednacinolone

Target: Glucocorticoid Receptor

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01585	SOD1 Protein, Human, Recombinant (His)	Human	E. coli
	SOD1 belongs to the Cu-Zn superoxide dismutase family. It binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmi...
TMPJ-00735	PDGF-BB Protein, Human, Recombinant	Human	E. coli
	Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (P...
TMPJ-00562	PDGF-BB Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (P...
TMPY-01104	Coagulation factor XI/F11 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the p...
TMPJ-00864	VEGF165 Protein, Human, Recombinant	Human	HEK293 Cells
	Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator...
TMPJ-01469	NGF Protein, Human, Recombinant (E. colli)	Mouse	E. coli
	NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family ...
TMPK-00876	G-CSFR/CD114 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	The Granulocyte Colony-Stimulating Factor (G-CSF) receptor, a member of the hematopoietin cytokine receptor superfamily, functions as a homodimer and requires the recruitment of cytosolic protein tyrosine kinases (PTKs) ...
TMPK-01178	PDGFD Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Platelet‑derived growth factor D (PDGF‑D) is a new member of the PDGF family that binds the PDGFR‑β homodimer. PDGF‑D promotes the angiogenic capacity of EPCs, including proliferation, migration, adhesion and tube format...
TMPY-04761	Creatine kinase B Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	CKB(Creatine kinase B type) contains 1 phosphagen kinase C-terminal domain and 1 phosphagen kinase N-terminal domain. It belongs to the ATP:guanido phosphotransferase family. CKB consists of a homodimer of two identical...
TMPJ-00586	SULT1A2 Protein, Human, Recombinant (His)	Human	E. coli
	Sulfotransferase 1A2 (SULT1A2) is a member of the Sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. SULT1A2 is a cy...
TMPJ-01300	PDCD10 Protein, Human, Recombinant	Human	E. coli
	Programmed Cell Death Protein 10 (PDCD10) belongs to the PDCD10 family. PDCD10 exists as a homodimer and is widely expressed. PDCD10 can increase mitogen-activated protein kinase activity and MST4 activity. PDCD10 is req...
TMPJ-01393	PGCP Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Carboxypeptidase Q (Cpq) is a member of the peptidase M28 family. PGCP is involved in a number of fundamental biological processes such as the hydrolysis of circulating peptides, catalyzing the hydrolysis of dipeptides w...
TMPJ-00784	Alkaline Phosphatase Protein, Human, Recombinant (aa 23-506, His)	Human	HEK293 Cells
	ALPP is a membrane protein and exits as a homodimer. ALPP is expressed only in normal term placenta, endocervix and fallopian tube and also in ovarian and proximal gastrointestinal tumors. It has been shown to play a rol...
TMPK-01278	CD69 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	CLEC2C (CD69) is a membrane-bound, type II C-lectin receptor and acts as a costimulatory molecule for T cell activation and proliferation. It is involved in lymphocyte proliferation and functions as a signal transmitting...
TMPJ-00479	KHK Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Ketohexokinase, also known as Hepatic fructokinase, is a member of the carbohydrate kinase PfkB family. It exits as a homodimer and most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found in adren...
TMPJ-00876	FAH Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Fumarylacetoacetase belongs to the FAH family. Fumarylacetoacetase is primary expressed in liver and kidney. It exists as a homodimer and catalyzes the hydrolysis of 4-fumarylacetoacetate into fumarate and acetoacetate. ...
TMPK-01259	S100A9 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	E. coli
	S100A8 and S100A9 (also known as MRP8 and MRP14, respectively) are Ca2 binding proteins belonging to the S100 family. They often exist in the form of heterodimer, while homodimer exists very little because of the stabili...
TMPK-01324	S100A9 Protein, Canine, Recombinant (His)	Canine	E. coli
	S100A8 and S100A9 (also known as MRP8 and MRP14, respectively) are Ca2 binding proteins belonging to the S100 family. They often exist in the form of heterodimer, while homodimer exists very little because of the stabili...
TMPK-00647	KIR3DL2 Protein, Rhesus macaque, Recombinant (His)	Rhesus	HEK293 Cells
	KIR3DL2 is a member of the killer cell immunoglobulin-like receptor (KIR) family that was initially identified at the surface of natural killer (NK) cells. KIR3DL2, also known as CD158k, is expressed as a disulfide-linke...
TMPK-00887	KIR3DL2 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	KIR3DL2 is a member of the killer cell immunoglobulin-like receptor (KIR) family that was initially identified at the surface of natural killer (NK) cells. KIR3DL2, also known as CD158k, is expressed as a disulfide-linke...
TMPJ-00868	PFKFB1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate...
TMPJ-01229	SUMF1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Human Sulfatase Modifying Factor 1 (SUMF1) is a 42kDa protein. SUMF1 is a Ca2+-binging member of the sulfatase-modifying factor family. SUMF1 is a soluble ER lumenal glycoprotein, it converts inactive sulfatases into an ...
TMPJ-01186	TRIM Protein, Human, Recombinant (His)	Human	E. coli
	T-Cell Receptor-Associated Transmembrane Adapter 1 (TRAT1) is a single-pass type III membrane protein. TRAT1 exists as a disulfide-linked homodimer and is strongly expressed in the thymus, and to a lesser extent in the s...
TMPJ-00757	Apolipoprotein A-II/APOA2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Apolipoprotein A-II(Apo-AII for short), also known as Apolipoprotein A2, is a secreted protein which belongs to the apolipoprotein A2 family. It exists as a disulfide-linked homodimer; and also can form a disulfide-linke...
TMPJ-01110	IRF5 Protein, Human, Recombinant (His)	Human	E. coli
	Interferon Regulatory Factor 5 (IRF5) is a member of the IRF family. It contains one IRF tryptophan pentad repeat DNA-binding domain. IRF5 shuttles between the nucleus and the cytoplasm. IRF5 can form homodimer when it ...
TMPJ-00826	TXN Protein, Human, Recombinant (His)	Human	E. coli
	Thioredoxin (TXN) is a member of the Thioredoxin family. Thioredoxin exists as a disulfide-linked homodimer and contains one Thioredoxin domain. Thioredoxin is up-regulated by ionizing radiation. Thioredoxin participates...
TMPJ-00690	PGDS Protein, Human, Recombinant	Human	E. coli
	Hematopoietic Prostaglandin D Synthase (HPGDS) belongs to the GST superfamily and Sigma family. HPGDS contains one GST C-terminal domain and one GST N-terminal domain. HPGDS is highly expressed in adipose tissue, macroph...
TMPH-01048	CEACAM5 Protein, Human, Recombinant (E398K, His)	Human	HEK293 Cells
	Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion mo...
TMPY-03329	DPEP1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Dehydropeptidase-I, also known as DPEP1, is a kidney membrane enzyme. Its expression in normal colonic mucosa is very low, but it is highly expressed in colorectal adenoma and cancer specimens and is negatively correl...
TMPJ-00964	PRCP Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Lysosomal Pro-X Carboxypeptidase (PRCP) belongs to the peptidase S28 family. PRCP is detected in many tissues, with highest levels observed in placenta, lung, and liver. It is also present in the heart, brain, pancreas, ...
TMPY-05752	SARS-CoV-2 3CLpro/3C-like protease Protein (His)	SARS-CoV-2	Baculovirus Insect Cells
	3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication an...
TMPY-05727	SARS-CoV-2 3CLpro/3C-like protease Protein (His & Avi)	SARS-CoV-2	E. coli
	3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication an...
TMPJ-01098	PRDX4 Protein, Human, Recombinant (His)	Human	E. coli
	Peroxiredoxin-4 (PRDX4) is a member of the AhpC/TSA family. PRDX4 is a cytoplasmic protein and contains one thioredoxin domain. PRDX4 exists in homodimer or heterodimer with PRDX1. PRDX4 reduces hydrogen peroxide and alk...
TMPY-03446	ENO3 Protein, Human, Recombinant (His)	Human	E. coli
	ENO3 is one of the three enolase isoenzymes found in mammals. As a homodimer, ENO3 is found in skeletal muscle cells in the adult. A switch from alpha enolase to beta enolase occurs in muscle tissue during development...
TMPJ-00898	CD72 Protein, Human, Recombinant (Trx & His)	Human	E. coli
	B-Cell Differentiation Antigen CD72 (CD72) is a single-pass type II membrane protein. CD72 exists as a disulfide-linked homodimer and contains one C-type lectin domain. CD72 is expressed on B lineage cells, NK cells, mon...
TMPJ-00460	MECR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Trans-2-Enoyl-CoA Reductase Mitochondrial (MECR) belongs to the zinc-containing alcohol dehydrogenase family. MECR localizes to the mitochondrion. It is highly expressed in skeletal and heart muscle and expressed at lowe...
TMPJ-00922	DCK Protein, Human, Recombinant (His & T7)	Human	E. coli
	Deoxycytidine Kinase (DCK) is a member of the DCK/DGK family. DCK exists as a homodimer and is localized to the nucleus. DCK is required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanos...
TMPJ-00961	STAT1 Protein, Human, Recombinant	Human	E. coli
	Signal Transducer and Activator of Transcription 1-Alpha/Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer term...
TMPH-03037	Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc)	Naja kaouthia	E. coli
	Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=...
TMPJ-00663	GDF-8 Protein, Human/Mouse/Rat, Recombinant	Human,Mouse,Rat	HEK293 Cells
	Growth/differentiation factor 8(Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site whi...
TMPJ-00721	ZBED1 Protein, Human, Recombinant (His)	Human	E. coli
	Zinc Finger BED Domain-Containing Protein 1 (ZBED1) contains one BED-type zinc finger and is found in the cell nucleus. ZBED1 is widely expressed, highly in heart, skeletal muscle, spleen and placenta. The expression of ...
TMPJ-01398	ITM2B Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other ti...
TMPJ-00938	4HPPD Protein, Human, Recombinant (His)	Human	E. coli
	4-Hydroxyphenylpyruvate Dioxygenase (4HPPD) belongs to the 4HPPD family. 4HPPD is a key enzyme in the degradation of tyrosine, which catalyzes the second reaction in the catabolism of tyrosine the conversation of 4-hydro...
TMPJ-01308	ITPase Protein, Human, Recombinant (His)	Human	E. coli
	Inosine Triphosphate Pyrophosphatase (ITPase) is a cytoplasmic enzyme that belongs to the HAM1 NTPase family. ITPase hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP) and deoxyinosine triphosphat...
TMPJ-00704	SCO1 Protein, Human, Recombinant (GST)	Human	E. coli
	Protein SCO1 Homolog, Mitochondrial (SCO1) is a member of the SCO1/2 family. SCO1 has a homodimer structure. SCO1 is located in mitochondrion and is highly expressed in muscle, heart, and brain. It is characterized by hi...
TMPJ-00762	ER alpha Protein, Human, Recombinant (His)	Human	E. coli
	Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and a...
TMPJ-01225	PDILT Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Protein Disulfide-Isomerase-Like Protein of the Testis (PDILT) is a protein that belongs to the protein disulfide isomerase family. Human PDILT is synthesized as a 584 amino acid precursor that contains an 20 amino acid ...
TMPJ-00813	QDPR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Dihydropteridine reductase, also known as HDHPR and Quinoid dihydropteridine reductase, QDPR and DHPR, belongs to the short-chain dehydrogenases/reductases (SDR) family. QDPR exists as a homodimer. QDPR is part of the pa...
TMPJ-00979	GSH-S Protein, Human, Recombinant (His)	Human	E. coli
	Glutathione Synthetase belongs to the eukaryotic GSH synthase family. Glutathione Synthetase is the second enzyme in the glutathione biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glyci...
TMPJ-00853	DAO Protein, Human, Recombinant (His)	Human	E. coli
	D-Amino-Acid Oxidase (DAO) belongs to the DAMOX/DASOX family. DAO is a peroxisomal enzyme which founctions as a homodimer to oxidizes D-amino acids to the corresponding imino acids, producing ammonia and hydrogen peroxid...
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