store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LG100754 (UVI 2112) is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functions as an agonist towards RXR: PPARα and RXR: PPARγ heterodimers.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 993.00 | |
50 mg | 6-8 weeks | $ 1,290.00 | |
100 mg | 6-8 weeks | $ 1,970.00 |
Description | LG100754 (UVI 2112) is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functions as an agonist towards RXR: PPARα and RXR: PPARγ heterodimers. |
In vitro | LG100754 functions as an activator of endogenous RXR heterodimers, specifically facilitating the activity of RXR: PPARγ heterodimers. It plays a crucial role in regulating insulin-dependent signaling pathways. Additionally, LG100754 has been shown to mitigate TNFα-mediated insulin resistance in mature adipocytes[1]. |
In vivo | LG100754 (100 mg/kg) fully blocks the enhance in glucose levels. It also shows that LG100754 can improve insulin resistance in vivo[1]. |
Synonyms | UVI 2112 |
Molecular Weight | 396.56 |
Formula | C26H36O3 |
CAS No. | 180713-37-5 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (227.0 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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LG100754 180713-37-5 DNA Damage/DNA Repair Metabolism PPAR LG-100754 UVI-2112 LG 100754 UVI2112 UVI 2112 inhibitor inhibit