efflux — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T72521	Efflux inhibitor-1
	Efflux inhibitor-1 is a pyrazolopyrimidine efflux inhibitor. Efflux inhibitor-1 selectively targets toward ABCG2/BCRP over ABCB1 with IC 50 s of 0.45 μM and 2.17 μM, respectively .
T5S0246	Pseudoprotodioscin		Others , Fatty Acid Synthase
	1. Pseudoprotodioscin has moderate cytotoxicity.		Others , Fatty Acid Synthase
T8596	Ceefourin 1		MRP
	Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.		MRP
T1050	Prazosin hydrochloride	Prazosin hydrochloride,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,Minipress	Potassium Channel , MRP , Adrenergic Receptor , ABC , Autophagy
	Prazosin hydrochloride (Vasoflex) reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not completely known. Prazosin hydrochloride is a synthetic ...
T16339	Norverapamil hydrochloride	(±)-Norverapamil hydrochloride,D591 hydrochloride	Calcium Channel , P-gp , Drug Metabolite
	Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.		Calcium Channel , P-gp , Drug Metabolite
T19768	γ-Tocotrienol	gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol	Others
	γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E. Itl is also a radioprotector, antioxidant. It shows antitumor and antihypertensive effects in vivo.		Others
TN3150	6,8-Diprenylnaringenin	Senegalensin,Lonchocarpol A	BCRP , ABC
	6,8-Diprenylnaringenin (Senegalensin) is a natural product from hop Humulus lupulus. 6,8-Diprenylnaringenin is a breast cancer resistance protein(BCRP) inhibitor with some estrogenicity.		BCRP , ABC
T12374	PAβN dihydrochloride	MC-207,110 dihydrochloride,Phe-Arg-β-naphthylamide dihydrochloride	Others , Antibacterial
	PAβN dihydrochloride (MC-207,110 dihydrochloride) is an inhibitor of efflux pump.		Others , Antibacterial
T16744	Rhodamine 6G	Basic Red 1	Others
	Rhodamine 6G (Basic Red 1) is a rhodamine analog useful in Pgp efflux assays. It can be widely used in characterizing the kinetics of MRP1- mediated efflux as a laser dye and potential mitochondrial probe.		Others
T14076	A 839977	A839977,A-839977	P2X Receptor , Calcium Channel
	A 839977 is a selective P2X7 receptor antagonist with anti-inflammatory and analgesic activity that inhibits BzATP-induced calcium efflux from the P2X7 receptor for the study of renal fibrosis.		P2X Receptor , Calcium Channel
T24542	NP-313	NP 313,NSC 4264,NSC-4264,NSC4264
	NP-313 (NSC-4264) is a potent antithrombotic agent that inhibits platelet aggregation and activation by inhibiting thromboxane A 2 synthesis and selectively inhibiting SOCC-mediated Ca2+ efflux.
T4818	Thyminose	2-Deoxy-D-ribose,2-Deoxy-D-arabinose,2-Deoxy-D-erythropentose	Others , Endogenous Metabolite
	Thyminose (2-Deoxy-D-arabinose) induces Apoptosis by inhibiting the synthesis and increasing the efflux of glutathione.		Others , Endogenous Metabolite
T9587	CCTA-1523		Others , ABC
	CCTA-1523 is an efflux function of ABCG2 inhibitor. CCTA-1523 selectively reverses ABCG2-mediated MDR in cancer cells.		Others , ABC
T16349	NSC-60339		Others , Antibacterial
	NSC-60339 is an inhibitor of efflux pump, and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeutic agent.		Others , Antibacterial
T8165	Erythrodiol		Endogenous Metabolite , ABC
	Erythrodiol, an olive oil component, promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein.		Endogenous Metabolite , ABC
TN1493	Chrysosplenol D		IL Receptor , NF-κB , JNK
	Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.		IL Receptor , NF-κB , JNK
T24170	Iodoantipyrine	Jodantipyrine,EINECS 204-966-6,Arthripur,Iodophenazone	Others
	Iodoantipyrine (Arthripur) is a commonly-used indicator and is used to evaluate in rats by measuring torcular venous efflux after systemic injection of the indicator under conditions of normal and high CBF.		Others
T4497	Amifampridine	3,4-Pyridinediamine,Pyridine-3,4-Diamine,3,4-Diaminopyridine	Others
	Amifampridine (3,4-Diaminopyridine) is predominantly in the treatment of a number of rare muscle diseases. Amifampridine works by blocking potassium channel efflux in nerve terminals so that action potential duration is ...		Others
T19554	L-Aspartic aicd sodium	L-Aspartic acid sodium,Sodium L-aspartate	Others , Sodium Channel , Endogenous Metabolite
	L-Aspartic aicd sodium (Sodium L-aspartate) is an amino acid, a precursor active molecule for colon-specific active molecule delivery, that promotes Na+ efflux from rat forebrain membrane vesicles.		Others , Sodium Channel , Endogenous Metabolite
T6S0095	Genkwanin	7-O-Methylapigenin,Puddumetin,Apigenin 7-methyl ether	Virus Protease
	1. Genkwanin (Apigenin 7-methyl ether) exerts its anti-inflammatory effect mainly through the regulation of the miR-11/MKP-1/MAPK pathway. 2. Genkwanin is transported by both passive diffusion and multidrug resistance pr...		Virus Protease