Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NP-313 (NSC-4264) is a potent antithrombotic agent that inhibits platelet aggregation and activation by inhibiting thromboxane A 2 synthesis and selectively inhibiting SOCC-mediated Ca2+ efflux.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 397.00 | |
50 mg | In stock | $ 589.00 | |
100 mg | In stock | $ 843.00 | |
500 mg | In stock | $ 1,730.00 |
Description | NP-313 (NSC-4264) is a potent antithrombotic agent that inhibits platelet aggregation and activation by inhibiting thromboxane A 2 synthesis and selectively inhibiting SOCC-mediated Ca2+ efflux. |
Targets&IC50 | COX-1:1.5 µM, TXA2:3.9 µM |
In vitro |
NP-313 (0-80 μM) can inhibit platelet aggregation in a dose-dependent manner. Among them, NP-313 can inhibit thrombin- and A23187-induced platelet aggregation to a maximum extent of about 80% and 60%, respectively.[1] NP-313 (0-8 μM) concentration-dependently inhibits P-selectin expression and collagen- or thrombin-induced thromboxane B 2 (TXB2) production in human platelets. Meanwhile, NP-313 inhibits COX-1 and TXA 2 synthase with IC50 values of 1.5 and 3.9 µM, respectively.[1] |
In vivo | NP-313 (4-16 µg/g; i.v.) significantly prolongs time-to-occlusion (TTO), prolongs bleeding time, and inhibits platelet aggregation induced by collagen (10 µg/mL) in male ICR mice.[1] |
Synonyms | NP 313, NSC 4264, NSC-4264, NSC4264 |
Molecular Weight | 249.65 |
Formula | C12H8ClNO3 |
CAS No. | 5397-78-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (240.34 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NP-313 5397-78-4 NP 313 NSC 4264 NSC-4264 NSC4264 NP313 inhibitor inhibit