breast — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T83892	33-BCRP Inhibitor	33-Breast Cancer Resistance Protein Inhibitor
	33-BCRP inhibitor is a compound that blocks the action of breast cancer resistance protein (BCRP), enhancing the susceptibility of mitoxantrone-resistant H460/MX20 lung cancer cells to the cytotoxic effects of mitoxantro...
T17258	WRG-28		Discoidin Domain Receptor (DDR)
	WRG-28 is a potent and selective, allosteric discoidin domain receptor 2 (ddr2) inhibitor(IC50 : 230 nM)		Discoidin Domain Receptor (DDR)
T9407	Rasarfin		Others , Ras
	Rasarfin inhibits Ras and ARF6.		Others , Ras
T15598	Isosulfan blue		Others
	Isosulfan blue is a blue dye for the identification of lymph vessels during lymphangiography. Isosulfan blue is used during sentinel lymph node biopsies in breast cancer. However, Isosulfan blue may be a cause of allergi...		Others
TQ0089	Juglanin		Apoptosis , JNK , Autophagy
	Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.		Apoptosis , JNK , Autophagy
TQ0186	Ko 143		BCRP , ABC
	Ko 143 is a selective inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2; BCRP).		BCRP , ABC
T9732	VY-3-135		Fatty Acid Synthase
	VY-3-135 is a metastasis inhibitor and an acetyl-CoA synthetase 2 (ACSS2) modulator.		Fatty Acid Synthase
T22336	Galloflavin		Dehydrogenase
	Galloflavin inhibits both the A and B isoforms of lactate dehydrogenase with Ki of 5.46 µM and 15.06 µM, respectively. Galloflavin is also a potential anticancer agent.		Dehydrogenase
T2168	2-(1,8-naphthyridin-2-yl)phenol		STAT
	2-NP is a STAT1 enhancer.		STAT
T5S1099	Liensinine		Apoptosis , Mitophagy , Others , Autophagy
	1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.		Apoptosis , Mitophagy , Others , Autophagy
T3581	KS176		Potassium Channel , BCRP
	KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter, showing no inhibitory activity against P-gp or MRP1.		Potassium Channel , BCRP
T13509	4-Vinylphenol		Apoptosis , Endogenous Metabolite
	4-Vinylphenol is the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine found in Hedyotis diffusa Willd. 4-Vinylphenol induces apoptosis in vivo.		Apoptosis , Endogenous Metabolite
T14765	BOS-172722		Kinesin
	BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).		Kinesin
T9468	FR054		Others
	FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and su...		Others
T22264	AZ9482		PARP
	AZ9482 is a selective and potent inhibitor of PARP featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent activity of centrosome declustering with EC50 of < 18 nM in HeLa cells.		PARP
T41256	SP-96		Aurora Kinase
	SP-96 is a highly effective and selective inhibitor of Aurora B with an IC50 of 0.316 nM. SP-96 shows selective growth inhibition in NCI60 screening, including MDA-MD-468 (GI50=107 nM). SP-96 can be used in triple negati...		Aurora Kinase
T5318	666-15	CREB inhibitor	Epigenetic Reader Domain
	666-15 (CREB inhibitor) is a potent and selective CREB inhibitor (IC50: 81 nM).		Epigenetic Reader Domain
TN1493	Chrysosplenol D		IL Receptor , NF-κB , JNK
	Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.		IL Receptor , NF-κB , JNK
T9629	BRD4 Inhibitor-24		Epigenetic Reader Domain
	BRD4 Inhibitor-24 is a BRD4 small molecule inhibitor with antitumor activity.		Epigenetic Reader Domain
T21804	GW 610		Others
	GW 610 is an antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines. In MCF-7 and MDA 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (GI50) < 0....		Others