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FR054

Catalog No. T9468 CAS 35954-65-5

FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and survival.

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FR054, CAS 35954-65-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 59.00
25 mg	In stock	$ 94.00
50 mg	In stock	$ 128.00
100 mg	In stock	$ 198.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

The effect of FR054 occurs through PGM3 inhibition instead of other off-target effects. FR054 (0.5-1 mM, 24-48 h) induces an early proliferation arrest followed by a marked cell death increase in breast cancer cells and induces apoptosis. FR054 (250?μM, 24 h) treatment efficiently affects both N- and O-glycosylation levels in MDA-MB-231 cells. FR054 induces endoplasmic reticulum stress and ROS-dependent apoptotic cell death [1].

Molecular Weight	329.3
Formula	C14H19NO8
CAS No.	35954-65-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 75 mg/mL (227.76 mM)

References and Literature

1. Francesca Ricciardiello, et al.Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis.Cell Death Dis . 2018 Mar 7;9(3):377.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Anti-Breast Cancer Compound Library Anti-Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

FR054 35954-65-5 Others TNBC HBP inhibit FR-054 FR 054 Negative Cancer Inhibitor Breast Triple PGM3 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.