20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1507 | Clematichinenoside AR | TNF , Autophagy | |
Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associated with collagen-induced arthritis. | |||
T12937 | SMS1-IN-1 | Others | |
SMS1-IN-1 is a potent inhibitor of sphingomyelin synthase 1 (SMS1, IC50 = 2.1 μM), and can be used in the atherosclerosis studies. | |||
T9108 | BI-0115 | Lipoxygenase | |
BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX... | |||
T6S1440 | Loganic acid | Loganate | Others |
1. Loganic acid (Loganate) and geniposide exhibit both sides effect on superoxide generation. | |||
TN6951 | Ethyl linoleate | Others | |
Ethyl linoleate is a natural product. | |||
T41358 | 2-Hydroxybenzylamine | Others | |
2-Hydroxybenzylamine, a potent small molecule scavenger of IsoLGs, sequesters the reactive species as inert adducts. 2-Hydroxybenzylamine may be used to decrease early recurrence of atrial fibrillation and other atrial a... | |||
T0463 | Loxoprofen | Loxoprofene,Loxoprofeno,Koloxo | COX |
Loxoprofen (Koloxo) is an anti-inflammatory non-steroidal medicine. | |||
TN1969 | N-(p-Coumaroyl) serotonin | PDGFR | |
N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower. N-(p-Coumaroyl) serotonin has antioxidant, cardioprotective effects after ischemia and antitumor activity, it may be beneficial in improving... | |||
T28410 | PHPS1 | PHPS-1,PHPS 1 | Phosphatase |
PHPS1 is an inhibitor of Shp2. PHPS1 efficiently inhibits activation of Erk1/2 by the leukemia-associated Shp2 mutant, Shp2-E76K, and blocks the anchorage-independent growth of a variety of human tumor cell lines. | |||
T15821 | LY518674 | LY-674 | PPAR |
LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα agonist (EC50: 42 nM for human PPARα). | |||
T7133 | Anagliptin | SK-0403 | Proteasome , DPP-4 |
Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus. | |||
T3982 | Vulpinic Acid | Vulpic acid,Pulvinic acid methyl ester | Others |
Vulpinic Acid (Pulvinic acid methyl ester) is a lichen metabolite with anti-inflammatory, antibacteria, properties, plant growth inhibitor. | |||
T0083 | Eplerenone | Epoxymexrenone,CGP 30083,SC-66110 | Glucocorticoid Receptor |
Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with transient elevations in serum aminotransferase ... | |||
TN6774 | Emodin 6-O-β-D-glucoside | Glucoemodin | Others |
Emodin 6-O-β-D-glucoside (Glucoemodin) can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside ... | |||
T1439 | Lacidipine | SN-305,GX-1048,GR-43659X | Apoptosis , Calcium Channel , Reactive Oxygen Species |
Lacidipine (SN-305) is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does not lead to reflex tachycardia. It displays specifi... | |||
T9010 | IMM-H007 | Others , AMPK | |
IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression | |||
T6690 | T0901317 | Apoptosis , FXR , Liver X Receptor , ROR | |
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB). | |||
T31677 | ESP-31015 | ESP 31015 | |
Esp-31015 may be used in the treatment of atherosclerosis. | |||
T68030 | Acitemate | Chinoin 123 | Others |
Acitemate(Chinoin 123) has an inhibitory effect on atherosclerosis and reduces the permeability of the aorta in rabbits fed a hyperlipidemic diet, which can be used to study atherosclerosis. | |||
T5505 | Terutroban | Prostaglandin Receptor | |
Terutroban, a thromboxane prostaglandin receptor antagonist, affects the progression of atherosclerosis. |