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Search Results for " atherosclerosis "

20

Compounds

Cat No. Product Name Synonyms Targets
TN1507 Clematichinenoside AR TNF , Autophagy
Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associated with collagen-induced arthritis.
T12937 SMS1-IN-1 Others
SMS1-IN-1 is a potent inhibitor of sphingomyelin synthase 1 (SMS1, IC50 = 2.1 μM), and can be used in the atherosclerosis studies.
T9108 BI-0115 Lipoxygenase
BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX...
T6S1440 Loganic acid Loganate Others
1. Loganic acid (Loganate) and geniposide exhibit both sides effect on superoxide generation.
TN6951 Ethyl linoleate Others
Ethyl linoleate is a natural product.
T41358 2-Hydroxybenzylamine Others
2-Hydroxybenzylamine, a potent small molecule scavenger of IsoLGs, sequesters the reactive species as inert adducts. 2-Hydroxybenzylamine may be used to decrease early recurrence of atrial fibrillation and other atrial a...
T0463 Loxoprofen Loxoprofene,Loxoprofeno,Koloxo COX
Loxoprofen (Koloxo) is an anti-inflammatory non-steroidal medicine.
TN1969 N-(p-Coumaroyl) serotonin PDGFR
N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower. N-(p-Coumaroyl) serotonin has antioxidant, cardioprotective effects after ischemia and antitumor activity, it may be beneficial in improving...
T28410 PHPS1 PHPS-1,PHPS 1 Phosphatase
PHPS1 is an inhibitor of Shp2. PHPS1 efficiently inhibits activation of Erk1/2 by the leukemia-associated Shp2 mutant, Shp2-E76K, and blocks the anchorage-independent growth of a variety of human tumor cell lines.
T15821 LY518674 LY-674 PPAR
LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα agonist (EC50: 42 nM for human PPARα).
T7133 Anagliptin SK-0403 Proteasome , DPP-4
Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus.
T3982 Vulpinic Acid Vulpic acid,Pulvinic acid methyl ester Others
Vulpinic Acid (Pulvinic acid methyl ester) is a lichen metabolite with anti-inflammatory, antibacteria, properties, plant growth inhibitor.
T0083 Eplerenone Epoxymexrenone,CGP 30083,SC-66110 Glucocorticoid Receptor
Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with transient elevations in serum aminotransferase ...
TN6774 Emodin 6-O-β-D-glucoside Glucoemodin Others
Emodin 6-O-β-D-glucoside (Glucoemodin) can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside ...
T1439 Lacidipine SN-305,GX-1048,GR-43659X Apoptosis , Calcium Channel , Reactive Oxygen Species
Lacidipine (SN-305) is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does not lead to reflex tachycardia. It displays specifi...
T9010 IMM-H007 Others , AMPK
IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression
T6690 T0901317 Apoptosis , FXR , Liver X Receptor , ROR
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
T31677 ESP-31015 ESP 31015
Esp-31015 may be used in the treatment of atherosclerosis.
T68030 Acitemate Chinoin 123 Others
Acitemate(Chinoin 123) has an inhibitory effect on atherosclerosis and reduces the permeability of the aorta in rabbits fed a hyperlipidemic diet, which can be used to study atherosclerosis.
T5505 Terutroban Prostaglandin Receptor
Terutroban, a thromboxane prostaglandin receptor antagonist, affects the progression of atherosclerosis.
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