Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PHPS1 is an inhibitor of Shp2. PHPS1 efficiently inhibits activation of Erk1/2 by the leukemia-associated Shp2 mutant, Shp2-E76K, and blocks the anchorage-independent growth of a variety of human tumor cell lines.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 44.00 | |
2 mg | In stock | $ 62.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 172.00 | |
25 mg | In stock | $ 363.00 | |
50 mg | In stock | $ 588.00 | |
100 mg | In stock | $ 839.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 127.00 |
Description | PHPS1 is an inhibitor of Shp2. PHPS1 efficiently inhibits activation of Erk1/2 by the leukemia-associated Shp2 mutant, Shp2-E76K, and blocks the anchorage-independent growth of a variety of human tumor cell lines. |
Targets&IC50 | SHP2:0.73 μM(Ki), SHP1:10.7 μM(Ki), PTP1B:5.8 μM(Ki), Shp2 (R362K):5.8 μM(Ki;Shp2-R362K), PTP1B Q:0.47 μM(Ki) |
In vitro | PHPS1 (30 μM; 6 days) inhibits proliferation of human tumor cells[1]. PHPS1 (5-20 μM; 5-360 minutes) inhibits Erk1/2 but not Akt and Stat3 phosphorylation in a dose-dependent manner[1]. |
In vivo | PHPS1 (3 mg/kg; i.p. injection; every day during the last week on the high-fat diet) renders Ldlr-/- mice less susceptible to atherosclerosis development[2]. |
Synonyms | PHPS-1, PHPS 1 |
Molecular Weight | 465.44 |
Formula | C21H15N5O6S |
CAS No. | 314291-83-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.25 mg/ml (34.91 mM)
You can also refer to dose conversion for different animals. More
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PHPS1 314291-83-3 Metabolism Phosphatase atherosclerosis kidney Erk1/2 PHPS-1 inhibit PTP1B prostate Shp1 colon lung Shp2 PHPS 1 carcinoma cancer Inhibitor inhibitor