anti-tumour — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4601	9-Methoxycanthin-6-one		Others
	9-Methoxycanthin-6-one has anti-tumour activity, exhibits cytotoxic activity towards KB, LU-1, LNCaP, HL-60 cancer cells and other human cancer cell lines with IC50 values around 1-4 μg/mL.		Others
T8684	Sotorasib	AMG-510	Ras
	Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib ...		Ras
T7194	CM-272		Apoptosis , DNA Methyltransferase , Histone Methyltransferase
	CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
T16813	RX-3117	fluorocyclopentenylcytosine,TV-1360	Nucleoside Antimetabolite/Analog
	RX-3117 (fluorocyclopentenylcytosine) is a novel a cytidine analog. RX-3117 displays anticancer activity in several cancer cell lines, including gemcitabine-resistant variants.		Nucleoside Antimetabolite/Analog
T8842	IMT1B	3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974	Others , DNA/RNA Synthesis
	IMT1B (LDC203974) is an orally administered, specific noncompetitive allosteric inhibitor of the mitochondrial RNA polymerase (POLRMT), effectively suppressing mitochondrial DNA (mtDNA) expression. This action confers it...		Others , DNA/RNA Synthesis
T26866	BMS-960	BMS 960,BMS960	S1P Receptor
	BMS-960 is an S1P agonist with potential anti-tumour activity for cancer research.		S1P Receptor
T28911	Tafetinib	SIM-010603,SIM010603,SIM 010603	Tyrosine Kinases
	Tafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity.		Tyrosine Kinases
T67699L	ALK/ROS1 inhibitor 2e HCL	(R)-1-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(trifluoromethoxy)benzyl)piperidine-3-carboxamide hydrochloride(2365497-12-5 Free base)	Apoptosis
	ALK/ROS1 inhibitor 2e HCL possesses anti-apoptotic, anti-proliferative and anti-tumour activities.		Apoptosis
T25384	Erbulozole	R-55104,R55104,R 55104	Microtubule Associated
	Erbulozole (R 55104) is a potent synthetic microtubule inhibitor with anti-invasive, anti-tumour and radiosensitising activity that induces Wernicke's encephalopathy-like neurotoxicity.		Microtubule Associated
T68152	Talmetacin		Others
	Talmetacin has anti-inflammatory and analgesic and anti-tumour activity and can be used to study cardiovascular disease.		Others
T14893	CC-885		Others , Ligand for E3 Ligase
	CC-885 is a modulator of cereblon (CRBN). It has potent anti-tumour activity.		Others , Ligand for E3 Ligase
T83646	(S)-OSMI 3	Ent-OSMI-3	Others
	(S)-OSMI 3 (Ent-OSMI-3) has anti-inflammatory and anti-tumour activity and can be used to study diabetes and neurodegenerative diseases.		Others
T25969	Poloxin-2	Poloxin2,Poloxin 2	PLK
	Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.		PLK
TN1582	Compound TN1582(SC)		Antiviral
	Dihydromollugin is a naphthol ester found in Rubia cordifolia that may have anti-tumour, virus-inhibiting and other activities.		Antiviral
T7670	Mavacoxib		COX
	Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity.		COX
T77728	Tubulin polymerization-IN-55		Microtubule Associated
	Tubulin polymerization-IN-55 is a potent Tubulin Polymerization inhibitor with potential anti-angiogenic and anti-tumour activity, showing anti-proliferative effects against A549, K562, HepG2, MDA-MB-231 and HFL-1.		Microtubule Associated
T7468	(-)-α-Terpineol	α-Terpineol	Others
	(-)-α-Terpineol has antitumour, anti-inflammatory, and antimicrobial activities, it inhibits the growth of tumour cells through a mechanism that involves inhibition of the NF-kappaB pathway		Others
T77407	Ensituximab	NPC-1C,NEO-102,NEO-101
	Ensituximab (NEO-102) is a quasi-selective IgG1 monoclonal antibody against the MUC5AC variant with anti-tumour activity that inhibits colorectal and pancreatic cancer.
T2798	Esculetin	Aesculetin,Cichorigenin	Lipoxygenase , Akt , PI3K
	Esculetin (Cichorigenin) is a coumarin derivative from various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lip...		Lipoxygenase , Akt , PI3K
T64167	Ifebemtinib	IN-10018,BI-853520	FAK
	Ifebemtinib (BI-853520) is an orally active and potent inhibitor of adhesion plaque kinase (FAK) (IC50=1 nM) with anti-tumour activity that inhibits globule formation and in situ tumour growth in malignant pleural mesoth...		FAK